|
gptkbp:instanceOf
|
gptkb:drug
antiemetic
|
|
gptkbp:approvalYear
|
2003 (US)
|
|
gptkbp:ATCCode
|
gptkb:A04AD12
|
|
gptkbp:brand
|
gptkb:Emend
|
|
gptkbp:CASNumber
|
gptkb:170729-80-3
|
|
gptkbp:developedBy
|
gptkb:Merck_&_Co.
|
|
gptkbp:drugInteraction
|
gptkb:warfarin
gptkb:dexamethasone
oral contraceptives
|
|
gptkbp:eliminationHalfLife
|
9–13 hours
|
|
gptkbp:excretion
|
urine
feces
|
|
gptkbp:form
|
capsule
oral suspension
|
|
gptkbp:hasMolecularFormula
|
C23H21F7N4O3
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
aprepitant
|
|
gptkbp:KEGGID
|
D02836
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
neurokinin-1 receptor antagonist
|
|
gptkbp:metabolism
|
liver (CYP3A4)
|
|
gptkbp:pregnancyCategory
|
B2 (Australia)
B (Australia)
|
|
gptkbp:proteinBinding
|
>95%
|
|
gptkbp:PubChem_CID
|
5293607
6918365
CHEMBL1476
DB00673
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
diarrhea
anorexia
constipation
fatigue
headache
hiccups
|
|
gptkbp:UNII
|
1L0O5XO1KE
|
|
gptkbp:usedFor
|
prevention of postoperative nausea and vomiting
prevention of chemotherapy-induced nausea and vomiting
|
|
gptkbp:bfsParent
|
gptkb:Emend
|
|
gptkbp:bfsLayer
|
5
|