|
gptkbp:instanceOf
|
antidepressant
serotonin antagonist and reuptake inhibitor
phenylpiperazine
|
|
gptkbp:ATCCode
|
N06AX06
|
|
gptkbp:brand
|
gptkb:Dutonin
gptkb:Serzone
Nefadar
Reseril
|
|
gptkbp:CASNumber
|
83366-66-9
|
|
gptkbp:category
|
antidepressants
serotonin receptor antagonists
phenylpiperazines
serotonin reuptake inhibitors
|
|
gptkbp:chemicalFormula
|
C25H32ClN5O2
|
|
gptkbp:developer
|
gptkb:Bristol-Myers_Squibb
|
|
gptkbp:eliminationHalfLife
|
2-4 hours
|
|
gptkbp:firstApproval
|
1994 (US)
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
nefazodone
|
|
gptkbp:KEGGID
|
D08206
|
|
gptkbp:legalStatus
|
withdrawn in US
withdrawn in EU
|
|
gptkbp:mechanismOfAction
|
norepinephrine reuptake inhibitor
serotonin 5-HT2A receptor antagonist
|
|
gptkbp:MeSH_ID
|
D019821
|
|
gptkbp:metabolism
|
gptkb:mCPP
gptkb:hydroxynefazodone
|
|
gptkbp:molecularWeight
|
469.01 g/mol
|
|
gptkbp:pregnancyCategory
|
C (US)
|
|
gptkbp:proteinBinding
|
99%
|
|
gptkbp:PubChem_CID
|
DB01149
CHEMBL1387
4448
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
nausea
constipation
dizziness
liver failure
drowsiness
dry mouth
|
|
gptkbp:synonym
|
nefazodone HCl
nefazodone hydrochloride
|
|
gptkbp:UNII
|
1W6M4QF8FY
|
|
gptkbp:usedFor
|
gptkb:major_depressive_disorder
|
|
gptkbp:withdrawn
|
hepatotoxicity
2003 (US)
|
|
gptkbp:bfsParent
|
gptkb:CYP3A5
|
|
gptkbp:bfsLayer
|
6
|