gptkbp:instanceOf
|
gptkb:receptor_tyrosine_kinase
gptkb:drug
|
gptkbp:approvalYear
|
2001
|
gptkbp:ATCCode
|
L01EA01
|
gptkbp:brand
|
gptkb:Gleevec
gptkb:Glivec
|
gptkbp:CASNumber
|
152459-95-5
|
gptkbp:chemicalFormula
|
phenylaminopyrimidine derivative
|
gptkbp:cost
|
high
|
gptkbp:developer
|
gptkb:Novartis
|
gptkbp:discoveredBy
|
gptkb:Brian_Druker
gptkb:Nicholas_Lydon
|
gptkbp:eliminationHalfLife
|
18 hours
|
gptkbp:excretion
|
urine
feces
|
gptkbp:firstSynthesized
|
1992
|
gptkbp:genericAvailable
|
yes
|
gptkbp:hasMolecularFormula
|
C29H31N7O
|
https://www.w3.org/2000/01/rdf-schema#label
|
imatinib
|
gptkbp:KEGGID
|
D08141
|
gptkbp:legalStatus
|
prescription only
|
gptkbp:mechanismOfAction
|
inhibits BCR-ABL tyrosine kinase
inhibits c-KIT
inhibits PDGFRA
|
gptkbp:metabolism
|
liver
|
gptkbp:molecularWeight
|
493.6 g/mol
|
gptkbp:patentExpired
|
2015
|
gptkbp:pregnancyCategory
|
D (US)
|
gptkbp:PubChem_CID
|
gptkb:CHEMBL941
gptkb:DB00619
5100
5291
|
gptkbp:routeOfAdministration
|
oral
|
gptkbp:sideEffect
|
nausea
diarrhea
edema
abdominal pain
fatigue
rash
muscle cramps
|
gptkbp:UNII
|
8CIP0O835V
|
gptkbp:usedFor
|
gptkb:gastrointestinal_stromal_tumor
gptkb:chronic_myeloid_leukemia
gptkb:systemic_mastocytosis
gptkb:dermatofibrosarcoma_protuberans
leukemia
hypereosinophilic syndrome
|
gptkbp:WHOModelListOfEssentialMedicines
|
yes
|
gptkbp:bfsParent
|
gptkb:BCR-ABL
gptkb:PDGFR
gptkb:PDGFRB
gptkb:CYP3A5
gptkb:Gleevec
gptkb:chronic_myeloid_leukemia
gptkb:CYP3A4_gene
gptkb:Platelet-derived_growth_factor
gptkb:PDGFRα
|
gptkbp:bfsLayer
|
6
|