DB06151

GPTKB entity

Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:drug
gptkbp:approvalYear 2012
gptkbp:ATCCode gptkb:J05AR14
gptkb:J05AR15
gptkbp:bioavailability high
gptkbp:CASNumber 1004316-88-4
gptkbp:component gptkb:Symtuza
gptkb:Evotaz
gptkb:Genvoya
gptkb:Stribild
gptkbp:drugClass CYP3A inhibitor
pharmacokinetic enhancer
inhibits CYP3A-mediated metabolism of coadministered drugs
gptkbp:eliminatedIn renal
fecal
gptkbp:halfLife 3-4 hours
gptkbp:hasInChIKey QMNWQGQMFQLOFV-UHFFFAOYSA-N
gptkbp:hasMolecularFormula C40H53N7O5S2
gptkbp:hasPharmGKBID PA162379255
gptkbp:hasSMILES CC(C)CN(C(=O)NC(C(=O)NC1CCCN1C(=O)C(Cc2ccccc2)NC(=O)C3CC3)CSC4=NC5=CC=CC=C5S4)C6=CC=CC=C6
gptkbp:hasUNII T1E1J9SG1G
https://www.w3.org/2000/01/rdf-schema#label DB06151
gptkbp:indication pharmacokinetic enhancer for HIV therapy
gptkbp:KEGGID D09741
gptkbp:legalStatus prescription only
patented
gptkbp:manufacturer gptkb:Gilead_Sciences
gptkbp:mechanismOfAction CYP3A inhibitor
gptkbp:meltingPoint ~138°C
gptkbp:molecularWeight 776.0
gptkbp:name gptkb:Cobicistat
gptkbp:pregnancyCategory B (US)
gptkbp:proteinBinding 98-99%
gptkbp:PubChem_CID gptkb:DB06151
28536938
25154809
CHEMBL2107727
gptkbp:routeOfAdministration oral
gptkbp:sideEffect nausea
jaundice
rash
increased serum creatinine
gptkbp:status true
gptkbp:synonym gptkb:GS-9350
gptkbp:target gptkb:CYP3A5
gptkb:P-glycoprotein
gptkb:CYP2D6
gptkb:CYP3A4
gptkbp:bfsParent gptkb:N-acetylcysteine
gptkbp:bfsLayer 6