Statements (32)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:receptor_tyrosine_kinase
gptkb:drug |
| gptkbp:approvalYear |
2009
|
| gptkbp:approvedBy |
gptkb:FDA
gptkb:EMA |
| gptkbp:ATCCode |
L01XE11
|
| gptkbp:brand |
gptkb:Votrient
|
| gptkbp:CASNumber |
444731-52-6
|
| gptkbp:discoveredBy |
GlaxoSmithKline
|
| gptkbp:hasMolecularFormula |
C21H23N7O2S
|
| https://www.w3.org/2000/01/rdf-schema#label |
pazopanib
|
| gptkbp:legalStatus |
prescription only
|
| gptkbp:mechanismOfAction |
inhibits PDGFR
inhibits c-Kit inhibits VEGFR |
| gptkbp:pregnancyCategory |
D (US)
|
| gptkbp:proteinBinding |
99%
|
| gptkbp:routeOfAdministration |
oral
|
| gptkbp:sideEffect |
nausea
diarrhea hypertension hepatotoxicity hair color changes |
| gptkbp:usedFor |
gptkb:rhabdomyosarcoma
renal cell carcinoma |
| gptkbp:bfsParent |
gptkb:PDGFRB
gptkb:CYP3A5 gptkb:VEGFR2 gptkb:KDR gptkb:Platelet-derived_growth_factor gptkb:Votrient |
| gptkbp:bfsLayer |
6
|