dasatinib

GPTKB entity

Statements (57)
Predicate Object
gptkbp:instanceOf gptkb:receptor_tyrosine_kinase
gptkb:drug
gptkbp:administeredBy oral
gptkbp:approvalYear 2006
gptkbp:approvedBy gptkb:United_States
gptkb:FDA
gptkbp:ATCCode L01EA02
gptkbp:bioavailability 14-34%
gptkbp:brand gptkb:Sprycel
gptkbp:CASNumber 302962-49-8
gptkbp:category protease inhibitor
antineoplastic agent
orphan drug
gptkbp:contraindication hypersensitivity to dasatinib
gptkbp:developedBy gptkb:Bristol-Myers_Squibb
gptkbp:discoveredBy gptkb:Bristol-Myers_Squibb
gptkbp:eliminationHalfLife 3-5 hours
gptkbp:excretion urine
feces
gptkbp:hasMolecularFormula C22H26ClN7O2S
https://www.w3.org/2000/01/rdf-schema#label dasatinib
gptkbp:interactsWith gptkb:proton_pump_inhibitors
CYP3A4 inhibitors
CYP3A4 inducers
antacids
H2 antagonists
gptkbp:KEGGID D03660
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction inhibits BCR-ABL tyrosine kinase
inhibits SRC family kinases
gptkbp:metabolism liver
gptkbp:patentExpired 2020s
gptkbp:pregnancyCategory gptkb:D_(Australia)
D (US)
gptkbp:proteinBinding 96%
gptkbp:PubChem_CID 3062316
CHEMBL1421
DB01254
2226510
gptkbp:riskFactor immunosuppression
teratogenicity
gptkbp:routeOfAdministration oral
gptkbp:sideEffect nausea
diarrhea
rash
QT prolongation
fluid retention
myelosuppression
gptkbp:synonym BMS-354825
gptkbp:UNII YR8S64M4FD
gptkbp:usedFor gptkb:chronic_myeloid_leukemia
gptkb:Philadelphia_chromosome-positive_acute_lymphoblastic_leukemia
gptkbp:bfsParent gptkb:BCR-ABL
gptkb:CYP3A5
gptkb:chronic_myeloid_leukemia
gptkb:CYP3A4_gene
gptkbp:bfsLayer 6