gefitinib

GPTKB entity

Statements (56)
Predicate Object
gptkbp:instanceOf gptkb:receptor_tyrosine_kinase
gptkb:drug
gptkbp:administeredBy oral
gptkbp:approvedBy gptkb:FDA
gptkb:EMA
2002
gptkbp:ATCCode L01XE02
gptkbp:bioavailability ~60%
gptkbp:brand gptkb:Iressa
gptkbp:CASNumber 184475-35-2
gptkbp:contraindication hypersensitivity to gefitinib
gptkbp:developedBy gptkb:AstraZeneca
gptkbp:discoveredBy gptkb:AstraZeneca
gptkbp:eliminationHalfLife 41 hours
gptkbp:excretion urine
feces
gptkbp:genericName gptkb:gefitinib
gptkbp:hasInChIKey YFSZZTSWQAGQDF-UHFFFAOYSA-N
gptkbp:hasMolecularFormula C22H24ClFN4O3
gptkbp:hasSMILES COC1=CC2=C(C=C1)N=C(NC3=CC=CC=C3F)N=C2OCCN4CCOCC4.Cl
gptkbp:hasUNII S2A4ZGM9G8
https://www.w3.org/2000/01/rdf-schema#label gefitinib
gptkbp:indication gptkb:EGFR_mutation-positive_non-small_cell_lung_cancer
gptkbp:KEGGID D00554
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction inhibits EGFR tyrosine kinase
gptkbp:MeSH_ID C477489
gptkbp:metabolism gptkb:CYP2D6
gptkb:CYP3A4
gptkbp:molecularWeight 446.9 g/mol
gptkbp:patent gptkb:AstraZeneca
gptkbp:pregnancyCategory gptkb:D_(Australia)
Not assigned (US)
gptkbp:proteinBinding 90%
gptkbp:PubChem_CID 110019
123631
CHEBI:49668
DB00317
gptkbp:routeOfAdministration oral
gptkbp:sideEffect nausea
vomiting
diarrhea
anorexia
rash
interstitial lung disease
gptkbp:synonym gptkb:ZD1839
gptkbp:target gptkb:epidermal_growth_factor_receptor
gptkbp:usedFor gptkb:non-small_cell_lung_cancer
gptkbp:bfsParent gptkb:EGFR
gptkb:EGFR_gene
gptkb:P15056
gptkb:P42338
gptkb:CYP3A5
gptkb:EGFR_signaling_pathway
gptkb:CYP3A4_gene
gptkbp:bfsLayer 6