sunitinib

GPTKB entity

Statements (58)
Predicate Object
gptkbp:instanceOf gptkb:receptor_tyrosine_kinase
gptkb:drug
gptkbp:administeredBy oral
gptkbp:approvedBy gptkb:FDA
gptkb:EMA
2006
gptkbp:ATCCode gptkb:L01XE04
gptkbp:brand gptkb:Sutent
gptkbp:CASNumber gptkb:557795-19-4
gptkbp:chemicalClass indolinone
gptkbp:color yellow powder
gptkbp:contraindication pregnancy
severe hepatic impairment
gptkbp:developedBy gptkb:Pfizer
gptkbp:discoveredBy gptkb:Sugen
gptkbp:eliminationHalfLife 40-60 hours
gptkbp:hasActiveMetabolite SU12662
gptkbp:hasMolecularFormula C22H27FN4O2
https://www.w3.org/2000/01/rdf-schema#label sunitinib
gptkbp:interactsWith CYP3A4 inhibitors
CYP3A4 inducers
gptkbp:KEGGID D06402
gptkbp:legalStatus prescription only
patent expired in US (2021)
gptkbp:mechanismOfAction inhibits multiple receptor tyrosine kinases
gptkbp:MeSH_ID C522097
gptkbp:metabolism gptkb:CYP3A4
gptkbp:pregnancyCategory D (US)
gptkbp:proteinBinding 95%
gptkbp:PubChem_CID 5329102
CHEMBL535
DB01268
gptkbp:routeOfAdministration oral
gptkbp:sideEffect gptkb:hand-foot_syndrome
nausea
vomiting
diarrhea
anorexia
fatigue
hypertension
rash
mucositis
gptkbp:solubility sparingly soluble in water
gptkbp:storage room temperature
gptkbp:UNII UH2A2J35Y7
gptkbp:usedFor gptkb:gastrointestinal_stromal_tumor
gptkb:pancreatic_neuroendocrine_tumors
renal cell carcinoma
gptkbp:bfsParent gptkb:PDGFR
gptkb:PDGFRB
gptkb:CYP3A5
gptkb:VEGFR2
gptkb:VEGF_signaling_pathway
gptkb:CYP3A4_gene
gptkb:KDR
gptkb:Platelet-derived_growth_factor
gptkb:PDGFRα
gptkbp:bfsLayer 6