constitutive androstane receptor

URI: https://gptkb.org/entity/constitutive_androstane_receptor
GPTKB entity
Statements (52)
Predicate Object
gptkbp:instanceOf gptkb:protein
nuclear receptor
gptkbp:activatedBy gptkb:rifampicin
gptkb:clotrimazole
phenobarbital
TCPOBOP
gptkbp:alternativeName CAR
NR1I3
gptkbp:discoveredBy 1998
gptkbp:encodedBy NR1I3 gene
gptkbp:expressedIn gptkb:kidney
liver
intestine
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function regulation of drug metabolism
regulation of xenobiotic metabolism
gptkbp:gene NR1I3
gptkbp:HGNC_ID 7970
https://www.w3.org/2000/01/rdf-schema#label constitutive androstane receptor
gptkbp:interactsWith retinoid X receptor alpha
gptkbp:locatedOnChromosome gptkb:chromosome_1q23.3
gptkbp:location gptkb:nucleus
gptkbp:member nuclear receptor subfamily 1 group I
gptkbp:OMIM 603898
gptkbp:PDB 1XV9
gptkbp:regulates gptkb:CYP2C9
gptkb:ABCB1
gptkb:CYP2C19
gptkb:ABCC2
gptkb:CYP2A6
gptkb:CYP3A4
gptkb:UGT1A1
gptkb:CYP7A1
gptkb:CYP2B6
gptkb:ABCG2
glucuronidation
sulfation
CYP8B1
SLCO1B1
bile acid metabolism
ALAS1
CYP2B10
GSTA1
SULT2A1
bilirubin clearance
drug transporter genes
glutathione conjugation
phase I and II drug-metabolizing enzymes
gptkbp:UniProtID Q14994
gptkbp:bfsParent gptkb:CYP3A5
gptkb:CYP3A
gptkbp:bfsLayer 6