Statements (93)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
transcription factor nuclear receptor |
| gptkbp:activates_transcription_of |
gptkb:ABCB1
gptkb:CYP3A4 gptkb:CYP2B6 |
| gptkbp:alternativeName |
gptkb:SXR
gptkb:PAR NR1I2 PXR |
| gptkbp:discoveredBy |
1998
|
| gptkbp:encodedBy |
NR1I2 gene
|
| gptkbp:expressedIn |
gptkb:breast
gptkb:large_intestine gptkb:peripheral_blood_leukocyte gptkb:thyroid gptkb:cancer gptkb:skin gptkb:pituitary_gland gptkb:skeletal_muscle gptkb:adrenal_gland gptkb:kidney gptkb:placenta gptkb:prostate gptkb:small_intestine gptkb:spinal_cord gptkb:testis gptkb:thymus brain eye heart liver spleen bladder bone marrow colon esophagus lymph node pancreas salivary gland stomach tongue intestine ear fetal liver fetal adrenal gland fetal bone marrow fetal brain fetal heart fetal intestine fetal kidney fetal lung fetal ovary fetal pancreas fetal pituitary gland fetal salivary gland fetal spleen fetal testis fetal thymus fetal thyroid fetal breast fetal ear fetal eye fetal lymph node fetal parathyroid fetal peripheral blood leukocyte fetal prostate fetal spinal cord fetal tongue parathyroid placental tissue |
| gptkbp:foundIn |
gptkb:Mus_musculus
gptkb:Homo_sapiens gptkb:Rattus_norvegicus |
| gptkbp:function |
regulation of expression of genes involved in drug metabolism
regulation of expression of genes involved in xenobiotic metabolism |
| gptkbp:gene |
NR1I2
|
| https://www.w3.org/2000/01/rdf-schema#label |
pregnane X receptor
|
| gptkbp:ligand |
gptkb:rifampicin
gptkb:hyperforin steroids phenobarbital xenobiotics pregnanes |
| gptkbp:locatedIn |
cell nucleus
|
| gptkbp:member |
nuclear receptor subfamily 1 group I member 2
|
| gptkbp:regulates |
lipid metabolism
glucose metabolism drug metabolism bile acid homeostasis |
| gptkbp:bfsParent |
gptkb:CYP3A5
gptkb:CYP3A |
| gptkbp:bfsLayer |
6
|