simvastatin

URI: https://gptkb.org/entity/simvastatin

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:drug statin
gptkbp:approvalYear	1991
gptkbp:approvedBy	gptkb:FDA
gptkbp:ATCCode	C10AA01
gptkbp:bioavailability	less than 5%
gptkbp:brand	gptkb:Zocor
gptkbp:CASNumber	79902-63-9
gptkbp:chemicalFormula	C25H38O5
gptkbp:contraindication	pregnancy active liver disease
gptkbp:developedBy	gptkb:lovastatin
gptkbp:discoveredBy	gptkb:Merck_&_Co.
gptkbp:drugClass	lipid-lowering agent
gptkbp:eliminationHalfLife	2 hours
gptkbp:essentialMedicine	gptkb:WHO_Model_List_of_Essential_Medicines
gptkbp:excretion	urine feces
gptkbp:firstSynthesized	1980s
https://www.w3.org/2000/01/rdf-schema#label	simvastatin
gptkbp:interactsWith	gptkb:milk gptkb:cyclosporine gptkb:warfarin gptkb:gemfibrozil gptkb:erythromycin
gptkbp:IUPACName	(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate
gptkbp:legalStatus	prescription only
gptkbp:mechanismOfAction	HMG-CoA reductase inhibitor
gptkbp:meltingPoint	135°C
gptkbp:metabolism	gptkb:CYP3A4
gptkbp:pregnancyCategory	gptkb:X_(US)
gptkbp:proteinBinding	95%
gptkbp:PubChem_CID	54454 DB00641
gptkbp:riskFactor	hepatotoxicity muscular dystrophy rhabdomyolysis
gptkbp:routeOfAdministration	oral
gptkbp:sideEffect	muscle pain digestive problems liver enzyme abnormalities
gptkbp:UNII	AGG2FN16EV
gptkbp:usedFor	lowering cholesterol prevention of cardiovascular disease
gptkbp:bfsParent	gptkb:CYP3A4 gptkb:Vytorin gptkb:Zocor
gptkbp:bfsLayer	5