|
gptkbp:instanceOf
|
antineoplastic agent
topoisomerase inhibitor
|
|
gptkbp:alternativeName
|
alkylating_agent
anticancer_drug
antimetabolite
antiparasitic_agent
antiprotozoal_agent
antitubercular_agent
chemotherapy_agent
chemotherapy_drug
etoposide
|
|
gptkbp:approvalYear
|
1983
|
|
gptkbp:approvedBy
|
gptkb:FDA
|
|
gptkbp:ATCCode
|
gptkb:L01CB01
|
|
gptkbp:CASNumber
|
gptkb:33419-42-0
|
|
gptkbp:chemicalFormula
|
C29H32O13
|
|
gptkbp:derivedFrom
|
gptkb:podophyllotoxin
|
|
gptkbp:discoveredBy
|
gptkb:Sandoz
|
|
gptkbp:excretion
|
gptkb:kidney
|
|
gptkbp:genericName
|
yes
|
|
gptkbp:KEGGID
|
gptkb:D00125
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
inhibits DNA topoisomerase II
|
|
gptkbp:MedlinePlusID
|
a684058
|
|
gptkbp:meltingPoint
|
261–265 °C
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:molecularWeight
|
588.56 g/mol
|
|
gptkbp:origin
|
semi-synthetic
|
|
gptkbp:pregnancyCategory
|
D (US)
|
|
gptkbp:PubChem_CID
|
gptkb:CHEMBL445
gptkb:DB00773
36462
|
|
gptkbp:routeOfAdministration
|
oral
intravenous
|
|
gptkbp:sideEffect
|
nausea
vomiting
hair loss
allergic reactions
low blood cell counts
|
|
gptkbp:synonym
|
gptkb:VP-16
|
|
gptkbp:UNII
|
6PLQ3CP4P3
|
|
gptkbp:usedFor
|
gptkb:cancer
leukemia
testicular cancer
Small Cell Lung Cancer
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
yes
|
|
gptkbp:bfsParent
|
gptkb:CYP3A4
gptkb:GemRIS
gptkb:taxol
gptkb:enzyme
gptkb:Lynparza
gptkb:Lenvima
gptkb:Tasigna
|
|
gptkbp:bfsLayer
|
5
|