|
gptkbp:instance_of
|
gptkb:pharmaceuticals
|
|
gptkbp:approves
|
gptkb:FDA
|
|
gptkbp:atccode
|
J02 AB02
|
|
gptkbp:available_on
|
generic
|
|
gptkbp:brand
|
gptkb:Nizoral
Ketozole
|
|
gptkbp:casnumber
|
65277-42-1
|
|
gptkbp:chemical_formula
|
C26 H28 Cl2 N4 O4
|
|
gptkbp:clinical_use
|
treatment of psoriasis
treatment of fungal infections
treatment of acne
treatment of dandruff
|
|
gptkbp:contraindication
|
liver disease
pregnancy
breastfeeding
|
|
gptkbp:developed_by
|
gptkb:Janssen_Pharmaceutica
|
|
gptkbp:discovery_year
|
gptkb:1976
|
|
gptkbp:duration
|
varies
|
|
gptkbp:excretion
|
urine
|
|
gptkbp:formulation
|
gptkb:cream
gptkb:tablet
gptkb:hair_care_product
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ketoconazole
|
|
gptkbp:interacts_with
|
gptkb:cyclosporine
gptkb:warfarin
benzodiazepines
statins
|
|
gptkbp:lifespan
|
2-3 hours
|
|
gptkbp:mechanism_of_action
|
inhibits ergosterol synthesis
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:name
|
Essential Medicines
|
|
gptkbp:route_of_administration
|
oral
topical
|
|
gptkbp:safety
|
Category C
|
|
gptkbp:side_effect
|
dizziness
fatigue
headache
nausea
abdominal pain
allergic reactions
fever
skin irritation
vomiting
diarrhea
liver toxicity
rash
itching
|
|
gptkbp:used_for
|
fungal infections
seborrheic dermatitis
candidiasis
tinea infections
|
|
gptkbp:bfsParent
|
gptkb:Biology
|
|
gptkbp:bfsLayer
|
3
|