|
gptkbp:instanceOf
|
antiviral drug
imidazole derivative
|
|
gptkbp:approvedBy
|
1981
|
|
gptkbp:ATCCode
|
gptkb:D01AC08
|
|
gptkbp:brand
|
gptkb:Nizoral
gptkb:Extina
gptkb:Xolegel
|
|
gptkbp:CASNumber
|
gptkb:65277-42-1
|
|
gptkbp:contraindication
|
gptkb:liver_disease
hypersensitivity to ketoconazole
|
|
gptkbp:discoveredBy
|
gptkb:Janssen_Pharmaceutica
|
|
gptkbp:drugInteraction
|
gptkb:proton_pump_inhibitors
gptkb:phenytoin
gptkb:rifampin
statins
anticoagulants
antacids
|
|
gptkbp:eliminationHalfLife
|
2 hours
|
|
gptkbp:excretion
|
urine
bile
|
|
gptkbp:hasMolecularFormula
|
gptkb:C26H28Cl2N4O4
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ketoconazole
|
|
gptkbp:IUPACName
|
gptkb:cis-1-acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine
|
|
gptkbp:KEGGID
|
gptkb:D00351
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
inhibits ergosterol synthesis
inhibits fungal cytochrome P450
|
|
gptkbp:MeSH_ID
|
gptkb:D007668
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:molecularWeight
|
531.43 g/mol
|
|
gptkbp:pregnancyCategory
|
C (US)
|
|
gptkbp:PubChem_CID
|
3691
3823
CHEMBL685
|
|
gptkbp:regulates
|
oral formulation withdrawn in several countries due to hepatotoxicity
|
|
gptkbp:riskFactor
|
QT prolongation
adrenal suppression
drug-induced hepatitis
|
|
gptkbp:routeOfAdministration
|
oral
topical
|
|
gptkbp:sideEffect
|
nausea
vomiting
abdominal pain
pruritus
hepatotoxicity
gynecomastia
adrenal insufficiency
|
|
gptkbp:UNII
|
R9400W9272
|
|
gptkbp:usedFor
|
treatment of fungal infections
treatment of dandruff
treatment of seborrheic dermatitis
treatment of tinea versicolor
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
yes
|
|
gptkbp:bfsParent
|
gptkb:CYP3_family
gptkb:CYP3A4
gptkb:Emend
gptkb:Imodium
|
|
gptkbp:bfsLayer
|
5
|