|
gptkbp:instanceOf
|
gptkb:drug
statin
|
|
gptkbp:approvalYear
|
1996
|
|
gptkbp:approvedBy
|
gptkb:FDA
|
|
gptkbp:ATCCode
|
gptkb:C10AA05
|
|
gptkbp:brand
|
gptkb:Lipitor
|
|
gptkbp:CASNumber
|
134523-00-5
|
|
gptkbp:chemicalFormula
|
C33H35FN2O5
|
|
gptkbp:contraindication
|
pregnancy
breastfeeding
active liver disease
|
|
gptkbp:cost
|
generic available
|
|
gptkbp:developedBy
|
gptkb:Pfizer
|
|
gptkbp:discoveredBy
|
gptkb:Bruce_Roth
|
|
gptkbp:drugInteraction
|
gptkb:milk
antifungals
certain antibiotics
|
|
gptkbp:eliminationHalfLife
|
14 hours
|
|
gptkbp:form
|
gptkb:tablet
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
atorvastatin
|
|
gptkbp:KEGGID
|
gptkb:D07481
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
HMG-CoA reductase inhibitor
|
|
gptkbp:MedlinePlusID
|
a600045
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:patentExpired
|
2011 (US)
|
|
gptkbp:pregnancyCategory
|
gptkb:X_(US)
|
|
gptkbp:prescribes
|
gptkb:familial_hypercholesterolemia
atherosclerosis
coronary artery disease
prevention of heart attack
prevention of stroke
dyslipidemia
hyperlipidemia
mixed dyslipidemia
primary hypercholesterolemia
|
|
gptkbp:PubChem_CID
|
gptkb:CHEMBL1487
60823
|
|
gptkbp:riskFactor
|
gptkb:diabetes_mellitus
memory problems
rhabdomyolysis
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
muscle pain
digestive problems
liver enzyme abnormalities
|
|
gptkbp:UNII
|
83HN0GTJ6D
|
|
gptkbp:usedFor
|
lowering cholesterol
prevention of cardiovascular disease
|
|
gptkbp:bfsParent
|
gptkb:CYP3A4
gptkb:Lipitor
|
|
gptkbp:bfsLayer
|
5
|