|
gptkbp:instanceOf
|
gptkb:drug
proton pump inhibitor
|
|
gptkbp:ATCCode
|
A02BC01
|
|
gptkbp:bioavailability
|
30–40%
|
|
gptkbp:brand
|
gptkb:Losec
gptkb:Prilosec
|
|
gptkbp:CASNumber
|
73590-58-6
|
|
gptkbp:category
|
gptkb:pharmacy
gastroenterology
|
|
gptkbp:chemicalFormula
|
benzoimidazole derivative
|
|
gptkbp:contraindication
|
hypersensitivity to omeprazole
|
|
gptkbp:discoveredBy
|
gptkb:Astra_AB
|
|
gptkbp:drugClass
|
proton pump inhibitor
|
|
gptkbp:drugInteraction
|
gptkb:phenytoin
gptkb:warfarin
gptkb:clopidogrel
gptkb:methotrexate
gptkb:diazepam
|
|
gptkbp:eliminationHalfLife
|
0.5–1 hour
|
|
gptkbp:excretion
|
urine
feces
|
|
gptkbp:firstPassMetabolism
|
yes
|
|
gptkbp:hasMolecularFormula
|
C17H19N3O3S
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
omeprazole
|
|
gptkbp:introducedIn
|
1988
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
inhibits H+/K+ ATPase
|
|
gptkbp:meltingPoint
|
155°C
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:pregnancyCategory
|
C (US)
|
|
gptkbp:prescriptionStatus
|
prescription only
|
|
gptkbp:proteinBinding
|
95%
|
|
gptkbp:routeOfAdministration
|
oral
intravenous
|
|
gptkbp:sideEffect
|
nausea
diarrhea
abdominal pain
constipation
headache
flatulence
|
|
gptkbp:solubility
|
practically insoluble in water
|
|
gptkbp:synonym
|
gptkb:Losec
gptkb:omeprazolum
gptkb:Prilosec
|
|
gptkbp:usedFor
|
gptkb:Zollinger-Ellison_syndrome
gptkb:erosive_esophagitis
gptkb:gastroesophageal_reflux_disease
gptkb:peptic_ulcer_disease
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
included
|
|
gptkbp:bfsParent
|
gptkb:CYP3A4
gptkb:riluzole
|
|
gptkbp:bfsLayer
|
5
|