gptkbp:instanceOf
|
statin
cholesterol-lowering drug
|
gptkbp:approvalYear
|
1987
|
gptkbp:approvedBy
|
gptkb:FDA
|
gptkbp:ATCCode
|
C10AA02
|
gptkbp:bioavailability
|
less than 5%
|
gptkbp:brand
|
gptkb:Altocor
gptkb:Mevacor
|
gptkbp:CASNumber
|
75330-75-5
|
gptkbp:category
|
gptkb:World_Health_Organization_essential_medicines
gptkb:Statins
Lipid-lowering agents
|
gptkbp:chemicalFormula
|
lactone ring
|
gptkbp:contraindication
|
pregnancy
active liver disease
|
gptkbp:discoveredBy
|
gptkb:Merck_&_Co.
|
gptkbp:drugClass
|
lipid-lowering agent
|
gptkbp:eliminationHalfLife
|
2-5 hours
|
gptkbp:firstStatinApproved
|
true
|
gptkbp:hasMolecularFormula
|
C24H36O5
|
https://www.w3.org/2000/01/rdf-schema#label
|
lovastatin
|
gptkbp:interactsWith
|
gptkb:milk
gptkb:cyclosporine
gptkb:gemfibrozil
gptkb:erythromycin
itraconazole
|
gptkbp:KEGGID
|
gptkb:D00351
|
gptkbp:legalStatus
|
prescription only
|
gptkbp:mechanismOfAction
|
HMG-CoA reductase inhibitor
|
gptkbp:metabolism
|
liver
|
gptkbp:origin
|
gptkb:Aspergillus_terreus
|
gptkbp:pregnancyCategory
|
gptkb:X_(US)
|
gptkbp:producedBy
|
fermentation
|
gptkbp:proteinBinding
|
>95%
|
gptkbp:PubChem_CID
|
53232
CHEMBL448
DB00227
|
gptkbp:riskFactor
|
muscular dystrophy
rhabdomyolysis
|
gptkbp:routeOfAdministration
|
oral
|
gptkbp:sideEffect
|
muscle pain
digestive problems
liver enzyme abnormalities
|
gptkbp:UNII
|
BKJ8M8G5HI
|
gptkbp:usedFor
|
gptkb:familial_hypercholesterolemia
prevention of cardiovascular disease
|
gptkbp:bfsParent
|
gptkb:CYP3A4
gptkb:Mevacor
|
gptkbp:bfsLayer
|
5
|