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gptkbp:instanceOf
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gptkb:enzyme
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gptkbp:alternativeName
|
gptkb:CYP3A5
cytochrome P450, family 3, subfamily A, polypeptide 5
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gptkbp:associatedWith
|
kidney disease
hypertension
drug response variability
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gptkbp:EC_number
|
1.14.14.1
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gptkbp:encodedBy
|
CYP3A5 gene
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gptkbp:expressedIn
|
gptkb:kidney
liver
intestine
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gptkbp:foundIn
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gptkb:Homo_sapiens
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gptkbp:function
|
monooxygenase activity
drug metabolism
xenobiotic metabolism
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gptkbp:gene
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gptkb:CYP3A5
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gptkbp:hasPolymorphism
|
CYP3A5*1
CYP3A5*3
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gptkbp:HGNC_ID
|
2597
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Cytochrome P450 3A5
|
|
gptkbp:inducedBy
|
gptkb:rifampicin
gptkb:phenytoin
gptkb:carbamazepine
|
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gptkbp:inhibitedBy
|
gptkb:clarithromycin
gptkb:ketoconazole
itraconazole
|
|
gptkbp:locatedIn
|
gptkb:endoplasmic_reticulum
|
|
gptkbp:locatedOnChromosome
|
chromosome 7q22.1
|
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gptkbp:member
|
gptkb:cytochrome_P450_superfamily
|
|
gptkbp:molecularWeight
|
57 kDa
|
|
gptkbp:OMIM
|
605340
|
|
gptkbp:orthologInMouse
|
Cyp3a11
Cyp3a1
|
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gptkbp:PDB
|
5VEU
|
|
gptkbp:RefSeq
|
NM_000777
|
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gptkbp:substrate
|
gptkb:nifedipine
gptkb:tacrolimus
gptkb:midazolam
testosterone
|
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gptkbp:UniProtID
|
P20815
|
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gptkbp:bfsParent
|
gptkb:CYP3A5
|
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gptkbp:bfsLayer
|
6
|