Statements (50)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:pharmaceuticals
|
| gptkbp:activities |
broad-spectrum
|
| gptkbp:administered_by |
oral tablet
intravenous injection |
| gptkbp:atccode |
J04 AB02
|
| gptkbp:available_on |
generic drug
|
| gptkbp:brand |
gptkb:Rifadin
gptkb:Rimactane |
| gptkbp:can_be_combined_with |
gptkb:ethambutol
gptkb:isoniazid gptkb:pyrazinamide |
| gptkbp:casnumber |
13292-46-1
|
| gptkbp:category |
gptkb:C
|
| gptkbp:chemical_formula |
C43 H58 N4 O12
|
| gptkbp:clinical_trial |
Phase III
|
| gptkbp:contraindication |
severe liver disease
hypersensitivity to rifampicin |
| gptkbp:developed_by |
gptkb:Daiichi_Sankyo
|
| gptkbp:discovered_by |
gptkb:1957
|
| gptkbp:duration |
6 to 12 months
|
| gptkbp:excretion |
urine
bile |
| https://www.w3.org/2000/01/rdf-schema#label |
rifampicin
|
| gptkbp:interacts_with |
gptkb:warfarin
oral contraceptives |
| gptkbp:lifespan |
2 to 5 hours
|
| gptkbp:mechanism_of_action |
inhibits bacterial RNA synthesis
|
| gptkbp:metabolism |
liver
|
| gptkbp:notable_feature |
can be used in HIV co-infection
can cause acute kidney injury can cause cholestatic jaundice can cause drug interactions can cause fever can cause flu-like symptoms can cause gastrointestinal disturbances can cause hypersensitivity reactions can cause rash can cause red man syndrome can cause thrombocytopenia induces cytochrome P450 enzymes potent against Mycobacterium tuberculosis used in multidrug-resistant TB treatment |
| gptkbp:produced_by |
gptkb:Amycolatopsis_rifamycinica
|
| gptkbp:side_effect |
hepatotoxicity
orange discoloration of bodily fluids |
| gptkbp:used_for |
treating leprosy
treating tuberculosis |
| gptkbp:water_resistance |
mutations in rpo B gene
|
| gptkbp:bfsParent |
gptkb:Biology
|
| gptkbp:bfsLayer |
3
|