Statements (50)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:drug
|
| gptkbp:bfsLayer |
3
|
| gptkbp:bfsParent |
gptkb:API
|
| gptkbp:activities |
broad-spectrum
inhibits bacterial RNA synthesis |
| gptkbp:appointed_by |
oral tablet
intravenous injection |
| gptkbp:brand |
gptkb:Rifadin
gptkb:Rimactane |
| gptkbp:can_be_used_with |
gptkb:ethambutol
gptkb:isoniazid gptkb:pyrazinamide |
| gptkbp:category |
gptkb:C
|
| gptkbp:clinical_trial |
Phase III
|
| gptkbp:contraindication |
severe liver disease
hypersensitivity to rifampicin |
| gptkbp:developed_by |
gptkb:Daiichi_Sankyo
|
| gptkbp:discovered_by |
gptkb:1957
|
| gptkbp:duration |
6 to 12 months
|
| gptkbp:excretion |
urine
bile |
| https://www.w3.org/2000/01/rdf-schema#label |
rifampicin
|
| gptkbp:ingredients |
C43 H58 N4 O12
|
| gptkbp:interacts_with |
gptkb:warfarin
oral contraceptives |
| gptkbp:is_atype_of |
J04 A B02
|
| gptkbp:is_available_on |
generic drug
|
| gptkbp:is_used_for |
treating leprosy
treating tuberculosis |
| gptkbp:lifespan |
2 to 5 hours
|
| gptkbp:metabolism |
liver
|
| gptkbp:notable_feature |
can be used in HIV co-infection
can cause acute kidney injury can cause cholestatic jaundice can cause drug interactions can cause fever can cause flu-like symptoms can cause gastrointestinal disturbances can cause hypersensitivity reactions can cause rash can cause red man syndrome can cause thrombocytopenia induces cytochrome P450 enzymes potent against Mycobacterium tuberculosis used in multidrug-resistant TB treatment |
| gptkbp:produced_by |
gptkb:Amycolatopsis_rifamycinica
|
| gptkbp:side_effect |
hepatotoxicity
orange discoloration of bodily fluids |
| gptkbp:type_of |
13292-46-1
|
| gptkbp:water_resistance |
mutations in rpo B gene
|