cytochrome P450 superfamily

GPTKB entity

Predicate	Object
gptkbp:instanceOf	superfamily
gptkbp:alsoKnownAs	CYP
gptkbp:cofactor	hemoglobin
gptkbp:contains	gptkb:cytochrome_P450_enzymes
gptkbp:database	gptkb:UniProt gptkb:Gene_Ontology:_GO:0004497 gptkb:InterPro:_IPR001128 gptkb:PROSITE:_PS00086 gptkb:Pfam:_PF00067
gptkbp:discoveredBy	gptkb:M._Klingenberg
gptkbp:discoveredIn	1958
gptkbp:EC_number	1.14.-.-
gptkbp:foundIn	gptkb:Bacteria archaea eukaryotes
gptkbp:function	monooxygenase activity
https://www.w3.org/2000/01/rdf-schema#label	cytochrome P450 superfamily
gptkbp:inducedBy	gptkb:rifampicin gptkb:carbamazepine phenobarbital
gptkbp:inhibitedBy	gptkb:milk azole antifungals
gptkbp:involvedIn	cholesterol metabolism detoxification steroid synthesis drug metabolism
gptkbp:locale	gptkb:endoplasmic_reticulum mitochondria bacterial cell membrane
gptkbp:namedFor	absorption peak at 450 nm
gptkbp:proteinFamily	gptkb:CYP1 gptkb:CYP11 gptkb:CYP17 gptkb:CYP19 gptkb:CYP2 gptkb:CYP21 gptkb:CYP24 gptkb:CYP27 gptkb:CYP3 gptkb:CYP4 gptkb:CYP46 gptkb:CYP51 gptkb:CYP7 CYP5
gptkbp:structure	contains heme prosthetic group
gptkbp:substrate	vitamins steroids fatty acids xenobiotics carcinogens
gptkbp:bfsParent	gptkb:CYP1A2 gptkb:CYP2C9 gptkb:CYP17_family gptkb:CYP19_family gptkb:CYP21_family gptkb:CYP51_family gptkb:CYP2D6 gptkb:CYP3A4
gptkbp:bfsLayer	5