|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:alias
|
gptkb:CYP3A
gptkb:Cytochrome_P450,_subfamily_IIIA,_polypeptide_4
gptkb:P450PCN1
|
|
gptkbp:catalyzes
|
drug metabolism
oxidation of xenobiotics
|
|
gptkbp:EC_number
|
1.14.14.1
|
|
gptkbp:encodedBy
|
gptkb:CYP3A4_gene
|
|
gptkbp:expressedIn
|
gptkb:hepatocytes
enterocytes
|
|
gptkbp:foundIn
|
liver
intestine
|
|
gptkbp:fullName
|
gptkb:Cytochrome_P450_3A4
|
|
gptkbp:gene
|
gptkb:CYP3A4
|
|
gptkbp:hasRole
|
drug-drug interactions
first-pass metabolism
|
|
gptkbp:HGNC_ID
|
2623
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CYP3A4
|
|
gptkbp:inducedBy
|
gptkb:phenytoin
gptkb:rifampin
gptkb:carbamazepine
gptkb:St._John's_Wort
|
|
gptkbp:inhibitedBy
|
gptkb:milk
gptkb:clarithromycin
gptkb:ketoconazole
itraconazole
|
|
gptkbp:locatedIn
|
gptkb:endoplasmic_reticulum
|
|
gptkbp:locatedOnChromosome
|
7q22.1
|
|
gptkbp:member
|
gptkb:cytochrome_P450_superfamily
|
|
gptkbp:molecularWeight
|
57 kDa
|
|
gptkbp:OMIM
|
124010
|
|
gptkbp:substrate
|
gptkb:cyclophosphamide
gptkb:everolimus
gptkb:sirolimus
gptkb:methadone
gptkb:budesonide
gptkb:ticagrelor
gptkb:citalopram
gptkb:paroxetine
gptkb:cyclosporine
gptkb:warfarin
gptkb:nifedipine
gptkb:rivaroxaban
gptkb:vardenafil
gptkb:omeprazole
gptkb:lidocaine
gptkb:atorvastatin
gptkb:sertraline
gptkb:sildenafil
gptkb:dexamethasone
gptkb:apixaban
gptkb:edoxaban
gptkb:clopidogrel
gptkb:pantoprazole
gptkb:tamoxifen
gptkb:amlodipine
gptkb:erythromycin
gptkb:tacrolimus
gptkb:verapamil
gptkb:midazolam
gptkb:amitriptyline
gptkb:aripiprazole
gptkb:cisapride
gptkb:dabigatran
gptkb:fluticasone
gptkb:ifosfamide
gptkb:imipramine
gptkb:lansoprazole
gptkb:methylprednisolone
gptkb:prasugrel
gptkb:pravastatin
gptkb:prednisolone
gptkb:rabeprazole
gptkb:tadalafil
gptkb:clozapine
gptkb:fluoxetine
gptkb:haloperidol
gptkb:quetiapine
gptkb:vincristine
gptkb:diazepam
gptkb:zolpidem
gptkb:losartan
gptkb:lovastatin
gptkb:simvastatin
gptkb:triazolam
gptkb:digoxin
gptkb:buprenorphine
quinidine
calcium channel blockers
statins
ethinylestradiol
cortisol
antineoplastic agent
fentanyl
diltiazem
docetaxel
indinavir
paclitaxel
saquinavir
alprazolam
testosterone
esomeprazole
|
|
gptkbp:UniProtID
|
P08684
|
|
gptkbp:bfsParent
|
gptkb:protein
|
|
gptkbp:bfsLayer
|
4
|