|
gptkbp:instanceOf
|
gptkb:anticoagulant
coumarin derivative
|
|
gptkbp:antidote
|
gptkb:vitamin_A
fresh frozen plasma
prothrombin complex concentrate
|
|
gptkbp:approvedBy
|
gptkb:FDA
1954
|
|
gptkbp:ATCCode
|
gptkb:B01AA03
|
|
gptkbp:brand
|
gptkb:Coumadin
gptkb:Jantoven
gptkb:Marevan
|
|
gptkbp:CASNumber
|
gptkb:81-81-2
|
|
gptkbp:category
|
gptkb:World_Health_Organization_essential_medicines
antithrombotic agent
|
|
gptkbp:chemicalFormula
|
C19H16O4
|
|
gptkbp:contraindication
|
pregnancy
uncontrolled hypertension
active bleeding
|
|
gptkbp:discoveredBy
|
gptkb:Karl_Paul_Link
|
|
gptkbp:discoveredIn
|
1940s
|
|
gptkbp:eliminationHalfLife
|
20-60 hours
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
warfarin
|
|
gptkbp:inhibitedBy
|
vitamin K epoxide reductase
|
|
gptkbp:interactsWith
|
gptkb:phenytoin
gptkb:NSAIDs
gptkb:aspirin
antibiotics
barbiturates
amiodarone
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
vitamin K antagonist
|
|
gptkbp:metabolism
|
gptkb:CYP2C9
liver
|
|
gptkbp:molecularWeight
|
308.33 g/mol
|
|
gptkbp:monitors
|
INR
|
|
gptkbp:pregnancyCategory
|
X
|
|
gptkbp:purpose
|
rodenticide
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
bleeding
bruising
purple toe syndrome
skin necrosis
|
|
gptkbp:usedFor
|
prevention of stroke in atrial fibrillation
treatment of deep vein thrombosis
treatment of pulmonary embolism
prevention of thromboembolism
prevention of thrombosis
prevention of stroke in patients with mechanical heart valves
|
|
gptkbp:bfsParent
|
gptkb:vitamin_A
|
|
gptkbp:bfsLayer
|
4
|