|
gptkbp:instanceOf
|
gptkb:Corticosteroid
|
|
gptkbp:approvedBy
|
1955
|
|
gptkbp:ATCCode
|
H02AB04
|
|
gptkbp:brand
|
Depo-Medrol
Medrol
Solu-Medrol
|
|
gptkbp:CASNumber
|
83-43-2
|
|
gptkbp:chemicalFormula
|
C22H30O5
|
|
gptkbp:contraindication
|
systemic fungal infections
|
|
gptkbp:discoveredBy
|
gptkb:Pfizer
|
|
gptkbp:drugClass
|
gptkb:Corticosteroid
|
|
gptkbp:eliminationHalfLife
|
18-36 hours
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
methylprednisolone
|
|
gptkbp:interactsWith
|
gptkb:cyclosporine
gptkb:phenytoin
gptkb:rifampin
gptkb:warfarin
gptkb:NSAIDs
live vaccines
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
reduces inflammation
binds to glucocorticoid receptor
modulates gene expression
suppresses immune response
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:molecularWeight
|
374.47 g/mol
|
|
gptkbp:pregnancyCategory
|
C (US)
|
|
gptkbp:routeOfAdministration
|
oral
intramuscular
intravenous
|
|
gptkbp:sideEffect
|
gptkb:bone
immunosuppression
hypertension
mood changes
weight gain
insomnia
hyperglycemia
|
|
gptkbp:usedFor
|
autoimmune diseases
lupus
rheumatoid arthritis
allergic reactions
organ transplant rejection
asthma exacerbations
inflammatory conditions
multiple sclerosis relapses
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
true
|
|
gptkbp:bfsParent
|
gptkb:CYP3A4
|
|
gptkbp:bfsLayer
|
5
|