cisapride

GPTKB entity

Statements (53)
Predicate Object
gptkbp:instanceOf gptkb:drug
gastroprokinetic agent
gptkbp:approvedBy 1988
gptkbp:ATCCode A03FA02
gptkbp:blackBoxWarning yes
gptkbp:brand Propulsid
gptkbp:CASNumber 81098-60-4
gptkbp:chemicalClass benzamide derivative
gptkbp:contraindication patients taking CYP3A4 inhibitors
patients with prolonged QT interval
gptkbp:discoveredBy gptkb:Janssen_Pharmaceutica
gptkbp:eliminationHalfLife 10 hours
gptkbp:excretion urine
feces
gptkbp:hasMolecularFormula C23H29ClFN3O4
https://www.w3.org/2000/01/rdf-schema#label cisapride
gptkbp:KEGGID D00216
gptkbp:legalStatus withdrawn in many countries
restricted use in some countries
gptkbp:mechanismOfAction 5-HT4 receptor agonist
increases acetylcholine release
gptkbp:metabolism gptkb:CYP3A4
gptkbp:molecularWeight 465.95 g/mol
gptkbp:pregnancyCategory C (US)
gptkbp:PubChem_CID 2667
2769
CHEMBL1327
DB00604
gptkbp:riskFactor electrolyte imbalance
pre-existing heart disease
concurrent use with CYP3A4 inhibitors
gptkbp:routeOfAdministration oral
gptkbp:sideEffect gptkb:arrhythmia
gptkb:torsades_de_pointes
nausea
diarrhea
abdominal pain
constipation
headache
QT prolongation
gptkbp:synonym Propulsid
cisapride monohydrate
gptkbp:UNII 3M8L1G6G0W
gptkbp:usedFor gptkb:gastroesophageal_reflux_disease
gastroparesis
gptkbp:withdrawn gptkb:Australia
gptkb:Canada
gptkb:European_Union
gptkb:India
gptkb:United_States
gptkbp:bfsParent gptkb:Erythromycin
gptkb:CYP3A4
gptkbp:bfsLayer 5