Statements (68)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:drug
|
| gptkbp:bfsLayer |
6
|
| gptkbp:bfsParent |
gptkb:Naltrexone
gptkb:ARX-01 gptkb:Suboxone_film gptkb:Suboxone gptkb:Subutex |
| gptkbp:antagonist |
mu-opioid receptor
kappa-opioid receptor |
| gptkbp:appointed_by |
gptkb:skincare_product
clinical settings sublingual tablet |
| gptkbp:approves |
gptkb:FDA
|
| gptkbp:associated_with |
ceiling effect
lower overdose risk |
| gptkbp:brand |
gptkb:Suboxone
gptkb:Subutex gptkb:Butrans |
| gptkbp:can_be_used_with |
gptkb:naloxone
|
| gptkbp:class |
partial agonist
|
| gptkbp:contraindication |
hypersensitivity
respiratory depression severe asthma |
| gptkbp:developed_by |
gptkb:Reckitt_Benckiser
|
| gptkbp:discovered_by |
1960s
|
| gptkbp:has_impact_on |
withdrawal symptoms
euphoria pain perception craving reduction |
| https://www.w3.org/2000/01/rdf-schema#label |
buprenorphine
|
| gptkbp:influences |
opioid receptors
|
| gptkbp:ingredients |
C29 H41 N O4 S
chronic opioid therapy |
| gptkbp:interacts_with |
CY P3 A4 inducers
CY P3 A4 inhibitors |
| gptkbp:is_analyzed_in |
pain management strategies
substance abuse interventions opioid pharmacology |
| gptkbp:is_available_in |
various formulations
|
| gptkbp:is_available_on |
generic medication
|
| gptkbp:is_considered_as |
first-line treatment
|
| gptkbp:is_evaluated_by |
safety
efficacy tolerability |
| gptkbp:is_part_of |
opioid replacement therapy
|
| gptkbp:is_recognized_by |
medical community
|
| gptkbp:is_studied_in |
pain relief
addiction treatment |
| gptkbp:is_subject_to |
gptkb:municipality
|
| gptkbp:is_used_by |
healthcare providers
|
| gptkbp:is_used_for |
pain management
opioid addiction treatment |
| gptkbp:legal_issue |
controlled substance
|
| gptkbp:lifespan |
24 to 60 hours
|
| gptkbp:manager |
oral
intravenous transdermal |
| gptkbp:marketed_as |
various brand names
|
| gptkbp:metabolism |
liver
|
| gptkbp:produced_by |
thebaine
|
| gptkbp:side_effect |
dizziness
headache nausea constipation |
| gptkbp:used_in |
chronic pain management
substance use disorder treatment medication-assisted treatment acute pain management |