apixaban

GPTKB entity

Statements (33)
Predicate Object
gptkbp:instanceOf gptkb:anticoagulant
factor Xa inhibitor
gptkbp:approvedBy gptkb:FDA
gptkb:EMA
2012
gptkbp:ATCCode B01AF02
gptkbp:bioavailability ~50%
gptkbp:brand gptkb:Eliquis
gptkbp:CASNumber 503612-47-3
gptkbp:contraindication active pathological bleeding
severe hepatic impairment
gptkbp:developedBy gptkb:Pfizer
gptkb:Bristol-Myers_Squibb
gptkbp:eliminationHalfLife ~12 hours
gptkbp:excretion urine
feces
gptkbp:hasMolecularFormula C25H25N5O4
https://www.w3.org/2000/01/rdf-schema#label apixaban
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction inhibits factor Xa
gptkbp:metabolism liver
gptkbp:molecularWeight 459.5 g/mol
gptkbp:pregnancyCategory B (Australia)
gptkbp:routeOfAdministration oral
gptkbp:sideEffect gptkb:anemia
nausea
bleeding
gptkbp:usedFor prevention of stroke in atrial fibrillation
treatment of deep vein thrombosis
treatment of pulmonary embolism
prevention of recurrent DVT and PE
gptkbp:bfsParent gptkb:CYP3A4
gptkbp:bfsLayer 5