|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:cytochrome_P450,_family_3,_subfamily_A,_polypeptide_4
|
|
gptkbp:associatedWith
|
pharmacogenomics
drug-drug interactions
|
|
gptkbp:encodes
|
gptkb:Cytochrome_P450_3A4
|
|
gptkbp:Entrez_Gene_ID
|
1576
|
|
gptkbp:enzymeCommissionNumber
|
gptkb:EC_1.14.14.1
|
|
gptkbp:expressedIn
|
liver
intestine
|
|
gptkbp:function
|
drug metabolism
steroid metabolism
xenobiotic metabolism
|
|
gptkbp:hasPolymorphism
|
CYP3A4*1B
CYP3A4*22
|
|
gptkbp:HGNC_ID
|
HGNC:2623
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CYP3A4 gene
|
|
gptkbp:inducedBy
|
gptkb:rifampicin
gptkb:phenytoin
gptkb:carbamazepine
|
|
gptkbp:inhibitedBy
|
gptkb:milk
gptkb:ketoconazole
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_7
7q22.1
|
|
gptkbp:memberOf
|
gptkb:cytochrome_P450_superfamily
|
|
gptkbp:OMIM
|
124010
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:regulates
|
constitutive androstane receptor (CAR)
pregnane X receptor (PXR)
|
|
gptkbp:substrate
|
gptkb:erlotinib
gptkb:everolimus
gptkb:gefitinib
gptkb:sirolimus
gptkb:temsirolimus
gptkb:methadone
gptkb:progesterone
gptkb:cyclosporine
gptkb:warfarin
gptkb:nifedipine
gptkb:dasatinib
gptkb:omeprazole
gptkb:benzodiazepines
gptkb:lidocaine
gptkb:atorvastatin
gptkb:clarithromycin
gptkb:ritonavir
gptkb:ethinyl_estradiol
gptkb:sorafenib
gptkb:tamoxifen
gptkb:estradiol
gptkb:carbamazepine
gptkb:erythromycin
gptkb:tacrolimus
gptkb:verapamil
gptkb:midazolam
gptkb:imatinib
gptkb:regorafenib
gptkb:sunitinib
gptkb:aripiprazole
gptkb:ifosfamide
gptkb:lapatinib
gptkb:bortezomib
gptkb:quetiapine
gptkb:vincristine
gptkb:buspirone
gptkb:diazepam
gptkb:lovastatin
gptkb:simvastatin
gptkb:triazolam
gptkb:vinblastine
gptkb:nilotinib
gptkb:vinorelbine
quinidine
calcium channel blockers
statins
ethinylestradiol
cortisol
antineoplastic agent
fentanyl
amiodarone
diltiazem
docetaxel
indinavir
paclitaxel
saquinavir
alprazolam
testosterone
cabazitaxel
ixabepilone
|
|
gptkbp:UniProtID
|
P08684
|
|
gptkbp:bfsParent
|
gptkb:CYP3A4
|
|
gptkbp:bfsLayer
|
5
|