|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:activeSiteResidue
|
iron atom
|
|
gptkbp:alternativeName
|
gptkb:P450_3A4
gptkb:cytochrome_P450,_family_3,_subfamily_A,_polypeptide_4
gptkb:CYP3A4
|
|
gptkbp:catalyzes
|
oxidation of small foreign organic molecules
|
|
gptkbp:cofactor
|
hemoglobin
|
|
gptkbp:EC_number
|
1.14.14.1
|
|
gptkbp:encodedBy
|
gptkb:CYP3A4_gene
|
|
gptkbp:expressedIn
|
gptkb:hepatocytes
enterocytes
|
|
gptkbp:foundIn
|
liver
intestine
|
|
gptkbp:function
|
drug metabolism
xenobiotic metabolism
|
|
gptkbp:gene
|
gptkb:CYP3A4
|
|
gptkbp:hasRole
|
drug-drug interactions
first-pass metabolism
|
|
gptkbp:HGNC_ID
|
2623
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Cytochrome P450 3A4
|
|
gptkbp:inducedBy
|
gptkb:rifampicin
gptkb:phenytoin
gptkb:carbamazepine
|
|
gptkbp:inhibitedBy
|
gptkb:milk
gptkb:ketoconazole
itraconazole
|
|
gptkbp:involves
|
cholesterol metabolism
bile acid synthesis
metabolism of over 50% of drugs
steroid metabolism
vitamin D metabolism
|
|
gptkbp:locatedIn
|
gptkb:endoplasmic_reticulum
|
|
gptkbp:locatedOnChromosome
|
7q22.1
|
|
gptkbp:member
|
gptkb:cytochrome_P450_superfamily
|
|
gptkbp:molecularWeight
|
57 kDa
|
|
gptkbp:OMIM
|
124010
|
|
gptkbp:orthologIn
|
gptkb:mouse
right
|
|
gptkbp:PDB
|
1TQN
|
|
gptkbp:polymorphisms_affect
|
drug metabolism rate
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:structure
|
X-ray crystallography
|
|
gptkbp:substrate
|
gptkb:cyclosporine
gptkb:erythromycin
gptkb:midazolam
statins
testosterone
|
|
gptkbp:target
|
pharmacogenomics studies
|
|
gptkbp:UniProtID
|
P08684
|
|
gptkbp:bfsParent
|
gptkb:CYP3A4
|
|
gptkbp:bfsLayer
|
5
|