sildenafil

GPTKB entity

Statements (55)
Predicate Object
gptkbp:instanceOf gptkb:chemical_compound
gptkb:drug
gptkbp:approvalYear 1998
gptkbp:approvedBy gptkb:FDA
gptkbp:ATCCode gptkb:G04BE03
gptkbp:availableOn gptkb:tablet
oral suspension
injectable
gptkbp:brand gptkb:Revatio
gptkb:Viagra
gptkbp:CASNumber 139755-83-2
gptkbp:chemicalClass gptkb:pyrazolopyrimidinone
gptkbp:contraindication nitrate medication
severe cardiovascular disorders
gptkbp:cost varies by country and brand
gptkbp:developedBy gptkb:United_Kingdom
gptkbp:discoveredBy gptkb:Pfizer
gptkbp:discoveredIn 1996
gptkbp:eliminationHalfLife 3-5 hours
gptkbp:excretion urine
feces
gptkbp:genericName yes
gptkbp:hasMolecularFormula C22H30N6O4S
https://www.w3.org/2000/01/rdf-schema#label sildenafil
gptkbp:interactsWith gptkb:milk
CYP3A4 inhibitors
nitrates
alpha-blockers
gptkbp:IUPACName gptkb:1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine
gptkbp:KEGGID D08514
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction PDE5 inhibitor
gptkbp:MeSH_ID D000068879
gptkbp:metabolism gptkb:CYP2C9
gptkb:CYP3A4
liver
gptkbp:notRecommendedFor children under 18 (for ED)
gptkbp:patentExpired 2013
gptkbp:pregnancyCategory B (US)
gptkbp:prescribes adults
gptkbp:PubChem_CID 5212
CHEMBL192
DB00203
gptkbp:routeOfAdministration oral
intravenous
gptkbp:sideEffect headache
dyspepsia
flushing
visual disturbances
gptkbp:UNII 3M7OB98Y7H
gptkbp:usedFor erectile dysfunction
pulmonary arterial hypertension
gptkbp:bfsParent gptkb:CYP3A4
gptkb:Viagra
gptkbp:bfsLayer 5