|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
biocatalyst
biological macromolecule
|
|
gptkbp:actsOn
|
gptkb:gene
|
|
gptkbp:alternativeName
|
enzyme_family
Enzyme
enzyme_complex
enzyme_inhibitor
enzyme_isoform
restriction_enzyme
ribozyme
topoisomerase
|
|
gptkbp:canBe
|
activated
allosteric
RNA molecule
constitutive
denatured
inducible
inhibited
repressible
|
|
gptkbp:composedOf
|
amino acids
|
|
gptkbp:discoveredBy
|
gptkb:Eduard_Buchner
gptkb:James_C._Wang
|
|
gptkbp:discoveredIn
|
1971
|
|
gptkbp:EC_number
|
Enzyme Commission number
5.99.1.2
|
|
gptkbp:example
|
gptkb:hexokinase
gptkb:protease
gptkb:lactase
gptkb:trypsin
reverse transcriptase
DNA polymerase
amylase
lipase
pepsin
catalase
|
|
gptkbp:foundIn
|
living organisms
prokaryotes
eukaryotes
|
|
gptkbp:function
|
catalyze biochemical reactions
alters DNA supercoiling
relieves DNA torsional strain
|
|
gptkbp:GO_term
|
gptkb:GO:0003916
|
|
gptkbp:hasComponent
|
active site
|
|
gptkbp:hasProperty
|
specificity
sensitivity to pH
sensitivity to temperature
|
|
gptkbp:hasType
|
gptkb:Type_II_topoisomerase
gptkb:Type_I_topoisomerase
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
enzyme
|
|
gptkbp:inhibitedBy
|
gptkb:camptothecin
ciprofloxacin
antineoplastic agent
|
|
gptkbp:measures
|
enzyme activity
|
|
gptkbp:namedFor
|
substrate
reaction type
|
|
gptkbp:requires
|
gptkb:coenzyme
metal ion
|
|
gptkbp:role
|
transcription
DNA replication
chromosome segregation
|
|
gptkbp:significance
|
cancer therapy target
antibiotic target
|
|
gptkbp:studiedIn
|
biochemistry
molecular biology
|
|
gptkbp:subclassOf
|
gptkb:hydrolase
gptkb:isomerase
gptkb:ligase
gptkb:translocase
lyase
oxidoreductase
transferase
|
|
gptkbp:Type_I_example
|
gptkb:topoisomerase_I
|
|
gptkbp:Type_I_mechanism
|
cuts one DNA strand
|
|
gptkbp:Type_II_example
|
gptkb:DNA_gyrase
gptkb:topoisomerase_II
|
|
gptkbp:Type_II_mechanism
|
cuts both DNA strands
|
|
gptkbp:usedIn
|
gptkb:biotechnology
gptkb:medicine
food industry
detergent industry
|
|
gptkbp:bfsParent
|
gptkb:protein
gptkb:software
gptkb:cathedral
|
|
gptkbp:bfsLayer
|
4
|