rifampin

GPTKB entity

Statements (54)
Predicate Object
gptkbp:instanceOf gptkb:antibiotic
gptkbp:alsoKnownAs gptkb:rifampicin
gptkbp:approvedBy gptkb:FDA
gptkbp:ATCCode gptkb:J04AB02
gptkbp:category gptkb:antibiotic
antineoplastic agent
antimycobacterial
gptkbp:chemicalFormula C43H58N4O12
gptkbp:combinationTherapy gptkb:isoniazid
gptkb:ethambutol
gptkb:pyrazinamide
streptomycin
gptkbp:contraindication gptkb:liver_disease
gptkbp:discoveredBy gptkb:Gabriele_Timbal
gptkb:Piero_Sensi
gptkbp:discoveredIn 1965
gptkbp:drugInteraction induces cytochrome P450 enzymes
gptkbp:eliminationHalfLife 3-5 hours
gptkbp:excretion urine
bile
https://www.w3.org/2000/01/rdf-schema#label rifampin
gptkbp:lactationUse use with caution
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction inhibits DNA-dependent RNA polymerase
gptkbp:metabolism liver
gptkbp:molecularWeight 822.94 g/mol
gptkbp:origin derived from rifamycin B
gptkbp:pregnancyCategory C
use with caution
gptkbp:producedBy gptkb:Amycolatopsis_mediterranei
gptkbp:resistantTo mutation in rpoB gene
gptkbp:riskFactor drug resistance if used alone
gptkbp:routeOfAdministration oral
intravenous
gptkbp:sideEffect hepatotoxicity
gastrointestinal upset
flu-like syndrome
hypersensitivity reactions
orange discoloration of body fluids
gptkbp:spectrumOfActivity gptkb:Haemophilus_influenzae
gptkb:Neisseria_meningitidis
gptkb:Mycobacterium_tuberculosis
gptkb:Staphylococcus_aureus
gptkbp:usedFor gptkb:MRSA_infections
tuberculosis
leprosy
meningococcal prophylaxis
gptkbp:WHOModelListOfEssentialMedicines included
gptkbp:bfsParent gptkb:rifampicin
gptkb:NNRTIs
gptkb:CYP3A4
gptkb:Brucellosis
gptkb:Emend
gptkbp:bfsLayer 5