Cytochrome P450, subfamily IIIA, polypeptide 4

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:alternativeName	gptkb:CYP3A4 P450-3A cytochrome P450 3A4
gptkbp:associatedWith	cholestasis adverse drug reaction drug-induced liver injury
gptkbp:cofactor	gptkb:cytochrome_P450_reductase NADPH
gptkbp:encodedBy	gptkb:CYP3A4_gene
gptkbp:enzymeCommissionNumber	gptkb:EC_1.14.14.1
gptkbp:expressedIn	liver intestine
gptkbp:family	gptkb:cytochrome_P450_superfamily
gptkbp:firstDescribed	1985
gptkbp:foundIn	gptkb:Homo_sapiens
gptkbp:function	monooxygenase activity drug metabolism xenobiotic metabolism
gptkbp:gene	gptkb:CYP3A4
gptkbp:geneType	protein-coding
gptkbp:HGNC_ID	2623
https://www.w3.org/2000/01/rdf-schema#label	Cytochrome P450, subfamily IIIA, polypeptide 4
gptkbp:inducedBy	gptkb:rifampicin gptkb:phenytoin gptkb:carbamazepine
gptkbp:inhibitedBy	gptkb:milk gptkb:ketoconazole
gptkbp:length	27 kb
gptkbp:locatedIn	gptkb:endoplasmic_reticulum
gptkbp:locatedOnChromosome	gptkb:chromosome_7q21.1
gptkbp:major_human_liver_P450	yes
gptkbp:molecularWeight	57 kDa
gptkbp:numberOfExons	13
gptkbp:OMIM	124010
gptkbp:orthologInMouse	Cyp3a11 Cyp3a1
gptkbp:PDB	1TQN
gptkbp:percentage_of_drug_metabolism	~30% of clinically used drugs
gptkbp:polypeptide	4
gptkbp:RefSeq	gptkb:NP_017539.1
gptkbp:subfamily	3A
gptkbp:substrate	gptkb:broadcaster gptkb:cyclosporine gptkb:erythromycin gptkb:midazolam statins testosterone
gptkbp:UniProtID	P08684
gptkbp:bfsParent	gptkb:CYP3A4
gptkbp:bfsLayer	5