clopidogrel

GPTKB entity

Statements (49)
Predicate Object
gptkbp:instanceOf gptkb:drug
gptkb:anticoagulant
gptkbp:approvalYear 1997
gptkbp:approvedBy gptkb:FDA
gptkbp:ATCCode B01AC04
gptkbp:bioavailability 50%
gptkbp:brand gptkb:Clopilet
gptkb:Plavix
Iscover
gptkbp:CASNumber 113665-84-2
gptkbp:chemicalFormula C16H16ClNO2S
gptkbp:contraindication severe liver impairment
active bleeding
gptkbp:developedBy gptkb:France
gptkbp:discoveredBy gptkb:Sanofi
gptkbp:drugClass thienopyridine
gptkbp:eliminationHalfLife 6 hours
gptkbp:excretion urine
feces
gptkbp:genericAvailable yes
https://www.w3.org/2000/01/rdf-schema#label clopidogrel
gptkbp:interactsWith gptkb:warfarin
gptkb:omeprazole
gptkb:aspirin
statins
esomeprazole
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction P2Y12 receptor antagonist
gptkbp:metabolism liver
active thiol metabolite
gptkbp:molecularWeight 321.82 g/mol
gptkbp:patentExpired 2012
gptkbp:pregnancyCategory B (US)
B1 (Australia)
gptkbp:proteinBinding 98%
gptkbp:riskFactor gastrointestinal bleeding
neutropenia
thrombotic thrombocytopenic purpura
gptkbp:routeOfAdministration oral
gptkbp:sideEffect diarrhea
bleeding
rash
bruising
gptkbp:usedFor prevention of stroke
prevention of myocardial infarction
prevention of peripheral arterial disease
gptkbp:WHOModelListOfEssentialMedicines yes
gptkbp:bfsParent gptkb:CYP3A4
gptkbp:bfsLayer 5