diazepam

GPTKB entity

Statements (54)
Predicate Object
gptkbp:instanceOf gptkb:drug
benzodiazepine
gptkbp:approvedBy gptkb:FDA
1963
gptkbp:ATCCode N05BA01
gptkbp:availableOn gptkb:tablet
oral solution
injectable solution
rectal gel
gptkbp:brand gptkb:Diastat
gptkb:Diazemuls
gptkb:Valium
gptkbp:CASNumber 439-14-5
gptkbp:contraindication gptkb:myasthenia_gravis
severe respiratory insufficiency
sleep apnea syndrome
severe hepatic insufficiency
gptkbp:controlledSubstanceSchedule Schedule IV (US)
gptkbp:discoveredBy gptkb:Leo_Sternbach
gptkbp:discoveredIn 1963
gptkbp:eliminationHalfLife 20-100 hours
gptkbp:excretion urine
gptkbp:hasMolecularFormula C16H13ClN2O
https://www.w3.org/2000/01/rdf-schema#label diazepam
gptkbp:KEGGID gptkb:D00293
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction positive allosteric modulator of GABA-A receptor
gptkbp:metabolism liver
gptkbp:molecularWeight 284.7 g/mol
gptkbp:pregnancyCategory D (US)
gptkbp:PubChem_CID gptkb:DB00829
2911
3016
CHEMBL26
49575
gptkbp:routeOfAdministration oral
intramuscular
intravenous
rectal
gptkbp:sideEffect fatigue
muscle weakness
drowsiness
impaired coordination
dependence
gptkbp:UNII Q3JTX2Q7TU
gptkbp:usedFor anxiety disorders
seizure disorders
muscle spasms
alcohol withdrawal
sedation before medical procedures
gptkbp:WHOModelListOfEssentialMedicines yes
gptkbp:bfsParent gptkb:Scottie_cramp
gptkb:CYP3A4
gptkbp:bfsLayer 5