|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:C-H-RAS
gptkb:Harvey_rat_sarcoma_viral_oncogene_homolog
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:Costello_syndrome
gptkb:head_and_neck_squamous_cell_carcinoma
bladder cancer
|
|
gptkbp:discoveredBy
|
gptkb:Harold_E._Varmus
gptkb:J._Michael_Bishop
|
|
gptkbp:encodes
|
gptkb:GTPase_HRas
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000174775
3265
|
|
gptkbp:fullName
|
gptkb:HRas_proto-oncogene,_GTPase
|
|
gptkbp:function
|
signal transduction
tumor suppressor
GTP binding
|
|
gptkbp:gene
|
gptkb:MRAS
gptkb:RALA
gptkb:RALB
gptkb:RIT1
gptkb:RIT2
gptkb:RRAS
gptkb:RRAS2
gptkb:KRAS
gptkb:NRAS
RERG
|
|
gptkbp:gene_location_(GRCh37)
|
chr11:534242-537576
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasTranscriptVariant
|
NM_005343.3
NM_176795.3
NM_176796.2
NM_176797.2
|
|
gptkbp:HGNC_ID
|
5173
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
3265 (HRAS)
|
|
gptkbp:interactsWith
|
gptkb:MAP2K1
gptkb:MAPK1
gptkb:NF1
gptkb:RAP1A
gptkb:RAP1B
gptkb:RAP2A
gptkb:RAP2B
gptkb:RAP2C
gptkb:RASA1
gptkb:RASSF5
gptkb:RIN1
gptkb:SOS2
gptkb:RIN2
gptkb:RIN3
gptkb:MAP2K2
gptkb:ARAF
gptkb:BRAF
gptkb:GRB2
gptkb:PIK3CA
gptkb:RAF1
gptkb:RALGDS
gptkb:SOS1
gptkb:RASSF1
gptkb:RASSF10
gptkb:RASSF2
gptkb:RASSF3
gptkb:RASSF4
gptkb:RASSF6
gptkb:RASSF7
gptkb:RASSF8
gptkb:RASSF9
|
|
gptkbp:length
|
189
|
|
gptkbp:locatedOnChromosome
|
gptkb:11p15.5
11
chr11:532242-535576
|
|
gptkbp:molecularWeight
|
21 kDa
|
|
gptkbp:mutationAssociatedWith
|
missense
germline
somatic
gain-of-function
oncogenic transformation
|
|
gptkbp:OMIM
|
190020
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Hras1
|
|
gptkbp:pathway
|
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
gptkb:Ras_signaling_pathway
|
|
gptkbp:postTranslationalModification
|
farnesylation
palmitoylation
phosphorylation
|
|
gptkbp:protein_structure
|
gptkb:Switch_II_region
gptkb:Switch_I_region
P-loop NTPase domain
|
|
gptkbp:proteinFamily
|
gptkb:Ras_family
gptkb:Ras_gene_family
GTPase domain
oncogene family
|
|
gptkbp:significance
|
benign
pathogenic
likely pathogenic
|
|
gptkbp:subcellularLocation
|
gptkb:Golgi_apparatus
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:symbol
|
gptkb:HRAS
|
|
gptkbp:UniProtID
|
gptkb:P01112
|
|
gptkbp:bfsParent
|
gptkb:RAS_gene
|
|
gptkbp:bfsLayer
|
5
|