|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:C-H-RAS
gptkb:HRAS1
gptkb:transforming_protein_p21
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:Costello_syndrome
gptkb:head_and_neck_squamous_cell_carcinoma
bladder cancer
|
|
gptkbp:discoveredBy
|
gptkb:Harold_E._Varmus
gptkb:J._Michael_Bishop
|
|
gptkbp:encodes
|
gptkb:GTPase_HRas
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000174775
3265
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:firstDescribed
|
1982
|
|
gptkbp:fullName
|
gptkb:Harvey_rat_sarcoma_viral_oncogene_homolog
|
|
gptkbp:function
|
signal transduction
regulation of cell differentiation
regulation of cell proliferation
regulation of cell survival
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
5173
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HRAS
|
|
gptkbp:interactsWith
|
gptkb:GAPs_(GTPase-activating_proteins)
gptkb:GEFs_(guanine_nucleotide_exchange_factors)
gptkb:GRB2
gptkb:PIK3CA
gptkb:RAF1
gptkb:SOS1
|
|
gptkbp:length
|
189 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:11p15.5
chromosome 11
|
|
gptkbp:memberOf
|
gptkb:RAS_gene_family
|
|
gptkbp:molecularWeight
|
21 kDa
|
|
gptkbp:mutationAssociatedWith
|
gain of function
germline mutation
missense mutation
somatic mutation
|
|
gptkbp:OMIM
|
190020
|
|
gptkbp:orthologInFruitFly
|
gptkb:Ras85D
|
|
gptkbp:orthologInMouse
|
gptkb:Hras1
|
|
gptkbp:orthologInYeast
|
gptkb:RAS2
|
|
gptkbp:postTranslationalModification
|
farnesylation
palmitoylation
phosphorylation
|
|
gptkbp:proteinFamily
|
small molecule
tumor suppressor
|
|
gptkbp:regulates
|
gptkb:MAPK/ERK_pathway
gptkb:PI3K/AKT_pathway
gptkb:RalGEF_pathway
|
|
gptkbp:subcellularLocation
|
gptkb:Golgi_apparatus
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:UniProtID
|
gptkb:P01112
|
|
gptkbp:bfsParent
|
gptkb:RAS
|
|
gptkbp:bfsLayer
|
4
|