|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:MCM7
gptkb:MCM7-related_protein
gptkb:PI3KCA
gptkb:p110-alpha
gptkb:phosphatidylinositol_4,5-bisphosphate_3-kinase_catalytic_subunit_alpha
gptkb:MCM
CLOVE
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:endometrial_cancer
gptkb:glioblastoma
colorectal cancer
|
|
gptkbp:discoveredBy
|
gptkb:Yoshihiro_Yano
|
|
gptkbp:discoveredIn
|
1993
|
|
gptkbp:encodes
|
gptkb:phosphatidylinositol-4,5-bisphosphate_3-kinase_catalytic_subunit_alpha_isoform
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000121879
5290
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:function
|
gptkb:catalytic_subunit_of_PI3K_alpha
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
gptkbp:HGNC_ID
|
8975
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PIK3CA
|
|
gptkbp:involves
|
gptkb:PI3K/AKT_signaling_pathway
cell survival
metabolism
angiogenesis
cell growth regulation
|
|
gptkbp:length
|
1068 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_3
3q26.32
|
|
gptkbp:memberOf
|
gptkb:phosphoinositide_3-kinase_family
|
|
gptkbp:molecularWeight
|
124 kDa
|
|
gptkbp:mutationAssociatedWith
|
germline mutation
somatic mutation
E542K
E545K
H1047R
|
|
gptkbp:OMIM
|
171834
|
|
gptkbp:orthologInMouse
|
gptkb:Pik3ca
|
|
gptkbp:product
|
gptkb:p110α
|
|
gptkbp:regulates
|
apoptosis
cell proliferation
cell cycle progression
cell migration
cell metabolism
|
|
gptkbp:targetOfDrug
|
gptkb:alpelisib
gptkb:buparlisib
gptkb:copanlisib
gptkb:idelalisib
gptkb:taselisib
|
|
gptkbp:UniProtID
|
gptkb:P42336
|
|
gptkbp:bfsParent
|
gptkb:cancer
gptkb:protein
|
|
gptkbp:bfsLayer
|
4
|