Harvey rat sarcoma viral oncogene homolog

URI: https://gptkb.org/entity/Harvey_rat_sarcoma_viral_oncogene_homolog
GPTKB entity
Statements (49)
Predicate Object
gptkbp:instanceOf gptkb:gene
gptkbp:alias gptkb:c-Ha-ras
gptkb:v-Ha-ras
gptkb:HRAS1
gptkbp:associatedWith gptkb:cancer
gptkb:Costello_syndrome
bladder cancer
head and neck cancer
gptkbp:discoveredBy gptkb:Harold_E._Varmus
gptkb:J._Michael_Bishop
gptkbp:encodes gptkb:GTPase_HRas
gptkbp:Entrez_Gene_ID gptkb:ENSG00000174775
3265
gptkbp:function signal transduction
cell differentiation regulation
cell proliferation regulation
gptkbp:geneType tumor suppressor
gptkbp:HGNC_ID 5173
https://www.w3.org/2000/01/rdf-schema#label Harvey rat sarcoma viral oncogene homolog
gptkbp:inhibitedBy gptkb:lonafarnib
gptkb:tipifarnib
gptkbp:length 189 amino acids
gptkbp:locatedOnChromosome chromosome 11
gptkbp:molecularWeight 21 kDa
gptkbp:mutationAssociatedWith constitutive activation
oncogenic mutation
uncontrolled cell growth
gptkbp:OMIM 190020
gptkbp:organism gptkb:Homo_sapiens
gptkbp:orthologIn gptkb:Mus_musculus
gptkb:Rattus_norvegicus
gptkbp:pathway gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
gptkbp:postTranslationalModification farnesylation
palmitoylation
gptkbp:product gptkb:HRas_protein
gptkbp:proteinFamily gptkb:Ras_family
GTPase domain
gptkbp:regulates gptkb:PI3K
gptkb:RalGDS
gptkb:RAF1
gptkbp:relatedTo gptkb:Kirsten_rat_sarcoma_viral_oncogene_homolog
gptkb:Neuroblastoma_RAS_viral_oncogene_homolog
gptkbp:subcellularLocation gptkb:plasma_membrane
gptkbp:symbol gptkb:HRAS
gptkbp:UniProtID gptkb:P01112
gptkbp:bfsParent gptkb:HRAS
gptkb:UniProt:P01112
gptkbp:bfsLayer 5