|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:discoveredBy
|
gptkb:Robert_Weinberg
gptkb:Michael_Wigler
|
|
gptkbp:encodes
|
gptkb:Ras_protein
|
|
gptkbp:encodesProteinWithFunction
|
GTPase activity
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:3265_(HRAS)
gptkb:3845_(KRAS)
gptkb:4893_(NRAS)
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:firstDescribed
|
1982
|
|
gptkbp:foundIn
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:hasIsoform
|
gptkb:HRAS
gptkb:KRAS
gptkb:NRAS
|
|
gptkbp:hasPathwayID
|
gptkb:KEGG:_hsa04014
gptkb:Reactome:_R-HSA-5673001
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
RAS gene
|
|
gptkbp:involvedIn
|
cell differentiation
cell signaling
cell growth regulation
oncogenesis
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_11_(HRAS)
gptkb:chromosome_12_(KRAS)
gptkb:chromosome_1_(NRAS)
|
|
gptkbp:memberOf
|
gptkb:RAS_gene_family
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:G12V
gptkb:G13D
colorectal cancer
pancreatic cancer
G12D
Q61R
|
|
gptkbp:OMIM
|
gptkb:164790_(NRAS)
gptkb:190020_(HRAS)
gptkb:190070_(KRAS)
|
|
gptkbp:orthologIn
|
gptkb:let-60_(C._elegans)
gptkb:ras85D_(Drosophila_melanogaster)
|
|
gptkbp:PDB
|
gptkb:5P21
4Q21
|
|
gptkbp:regulates
|
gptkb:Guanine_nucleotide_exchange_factors_(GEFs)
gptkb:MAPK/ERK_pathway
gptkb:PI3K/AKT_pathway
GTPase-activating proteins (GAPs)
|
|
gptkbp:target
|
gptkb:MEK_inhibitors
farnesyltransferase inhibitors
anticancer drugs
|
|
gptkbp:UniProtID
|
gptkb:P01111_(NRAS)
gptkb:P01112_(HRAS)
P01116 (KRAS)
|
|
gptkbp:bfsParent
|
gptkb:cancer
|
|
gptkbp:bfsLayer
|
4
|