|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:alternativeName
|
gptkb:Harvey_rat_sarcoma_viral_oncogene_homolog
gptkb:Transforming_protein_p21
|
|
gptkbp:discoveredBy
|
gptkb:Harold_E._Varmus
gptkb:J._Michael_Bishop
|
|
gptkbp:discoveredIn
|
1982
|
|
gptkbp:encodedBy
|
gptkb:HRAS_gene
|
|
gptkbp:Entrez_Gene_ID
|
3265
|
|
gptkbp:enzymeCommissionNumber
|
gptkb:EC_3.6.5.2
|
|
gptkbp:form
|
GTP-bound
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
signal transduction
GTP binding
GTPase activity
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
GTPase HRas
|
|
gptkbp:inactiveForm
|
GDP-bound
|
|
gptkbp:interactsWith
|
gptkb:GAPs
gptkb:GEFs
gptkb:PI3K
gptkb:RAF1
gptkb:SOS1
|
|
gptkbp:locatedOnChromosome
|
gptkb:11p15.5
|
|
gptkbp:location
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:memberOf
|
gptkb:Ras_superfamily
gptkb:small_GTPase_family
|
|
gptkbp:molecularWeight
|
21 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:Costello_syndrome
bladder cancer
head and neck cancer
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
gptkb:5P21
|
|
gptkbp:postTranslationalModification
|
farnesylation
palmitoylation
|
|
gptkbp:regulates
|
apoptosis
cell differentiation
cell proliferation
cell survival
|
|
gptkbp:structure
|
monomeric
|
|
gptkbp:UniProtID
|
gptkb:P01112
|
|
gptkbp:bfsParent
|
gptkb:HRAS
gptkb:UniProt:P01112
|
|
gptkbp:bfsLayer
|
5
|