|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
guanine nucleotide exchange factors (GEFs)
|
|
gptkbp:decommissioned
|
GTPase-activating proteins (GAPs)
|
|
gptkbp:discoveredIn
|
1980s
|
|
gptkbp:encodes
|
gptkb:Ras_proteins
|
|
gptkbp:foundIn
|
eukaryotes
|
|
gptkbp:function
|
signal transduction
|
|
gptkbp:hasParalog
|
gptkb:MRAS
gptkb:RALA
gptkb:RALB
gptkb:RAP1A
gptkb:RAP1B
gptkb:RAP2A
gptkb:RAP2B
gptkb:RAP2C
gptkb:RAPGEF1
gptkb:RHEB
gptkb:RHEBL1
gptkb:RIT1
gptkb:RIT2
gptkb:RND1
gptkb:RND2
gptkb:RND3
gptkb:RRAS
gptkb:RRAS2
RERG
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Ras gene family
|
|
gptkbp:includes
|
gptkb:HRAS
gptkb:KRAS
gptkb:NRAS
|
|
gptkbp:involvedIn
|
cell differentiation
cell survival
cell growth regulation
|
|
gptkbp:locatedOnChromosome
|
HRAS: 11p15.5
KRAS: 12p12.1
NRAS: 1p13.2
|
|
gptkbp:memberOf
|
gptkb:small_GTPase_superfamily
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
codon 12
codon 13
codon 61
|
|
gptkbp:namedAfter
|
gptkb:rat_sarcoma_virus
|
|
gptkbp:product
|
gptkb:G_protein-coupled_receptor
|
|
gptkbp:regulates
|
gptkb:MAPK/ERK_pathway
gptkb:PI3K/AKT_pathway
apoptosis
cell proliferation
vesicle trafficking
cytoskeletal organization
|
|
gptkbp:relatedTo
|
oncogenesis
|
|
gptkbp:bfsParent
|
gptkb:RAS
|
|
gptkbp:bfsLayer
|
4
|