|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:GADS
gptkb:Grb-2
gptkb:ASH
|
|
gptkbp:associatedWith
|
gptkb:cancer
leukemia
|
|
gptkbp:discoveredBy
|
gptkb:Tony_Pawson
|
|
gptkbp:discoveredIn
|
1992
|
|
gptkbp:domain
|
SH2 domain
SH3 domain
|
|
gptkbp:encodedBy
|
gptkb:GRB2_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000177885
|
|
gptkbp:essentialGene
|
yes
|
|
gptkbp:foundIn
|
all human tissues
|
|
gptkbp:fullName
|
gptkb:Growth_factor_receptor-bound_protein_2
|
|
gptkbp:function
|
adaptor protein in signal transduction
|
|
gptkbp:gene
|
gptkb:GRB2
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasParalog
|
gptkb:GAB1
gptkb:GAB2
|
|
gptkbp:HGNC_ID
|
4566
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
GRB2
|
|
gptkbp:interactsWith
|
gptkb:BCR-ABL
gptkb:EGFR
gptkb:SHC1
gptkb:c-Met
gptkb:SOS1
|
|
gptkbp:involvedIn
|
gptkb:RAS_signaling_pathway
gptkb:MAPK_signaling_pathway
|
|
gptkbp:length
|
217
|
|
gptkbp:locatedOnChromosome
|
gptkb:17q25
|
|
gptkbp:location
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:molecularWeight
|
25 kDa
|
|
gptkbp:mutationAssociatedWith
|
disrupts signal transduction
|
|
gptkbp:OMIM
|
108355
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:pathway
|
EGFR signaling
FGFR signaling
PDGFR signaling
T-cell receptor signaling
insulin signaling
|
|
gptkbp:PDB
|
gptkb:1GRI
|
|
gptkbp:postTranslationalModification
|
phosphorylation
|
|
gptkbp:regulates
|
apoptosis
cell differentiation
cell proliferation
cell migration
|
|
gptkbp:UniProtID
|
gptkb:P62993
|
|
gptkbp:bfsParent
|
gptkb:HRAS
|
|
gptkbp:bfsLayer
|
5
|