Statements (59)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:DNA
|
| gptkbp:associated_with |
gptkb:Oncology
|
| gptkbp:code |
gptkb:Kirsten_rat_sarcoma_viral_oncogene_homolog
|
| gptkbp:function |
regulates cell division
|
| gptkbp:genetic_studies |
gptkb:Oncology
gptkb:lung_adenocarcinoma ovarian cancer common in lung cancer common in colorectal cancer common in pancreatic cancer |
| gptkbp:has_role |
tumorigenesis
|
| gptkbp:has_variants |
gptkb:KRAS_A146_T
gptkb:KRAS_G12_D gptkb:KRAS_G12_V gptkb:KRAS_G13_D gptkb:KRAS_Q61_H |
| https://www.w3.org/2000/01/rdf-schema#label |
KRAS
|
| gptkbp:interacts_with |
gptkb:SOS1
gptkb:Raf_kinase gptkb:PIK3_CA gptkb:RAF1 |
| gptkbp:involved_in |
MAPK signaling pathway
Ras signaling pathway apoptosis cell differentiation cell proliferation |
| gptkbp:is_associated_with |
tumor microenvironment
poor prognosis |
| gptkbp:is_essential_for |
cell survival
|
| gptkbp:is_expressed_in |
various tissues
breast tissues colorectal tissues lung tissues ovarian tissues pancreatic tissues |
| gptkbp:is_involved_in |
cell cycle regulation
cell signaling immune response inflammation angiogenesis cell migration drug resistance |
| gptkbp:is_linked_to |
metastasis
radiation resistance chemotherapy resistance |
| gptkbp:is_part_of |
precision medicine
cancer genomics Ras superfamily oncogenic signaling pathways |
| gptkbp:is_regulated_by |
guanine nucleotide exchange factors
GTPase activating proteins |
| gptkbp:is_studied_for |
therapeutic interventions
|
| gptkbp:is_studied_in |
clinical trials
cancer research |
| gptkbp:is_targeted_at |
targeted therapies
KRAS inhibitors |
| gptkbp:located_in |
human chromosome 12
|
| gptkbp:bfsParent |
gptkb:pancreatic_cancer
|
| gptkbp:bfsLayer |
4
|