|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:NS
gptkb:Ki-ras
gptkb:RASK2
gptkb:c-K-ras
|
|
gptkbp:associatedWith
|
gptkb:Cardiofaciocutaneous_syndrome
gptkb:Costello_syndrome
gptkb:Noonan_syndrome
|
|
gptkbp:discoveredBy
|
gptkb:Harold_E._Varmus
gptkb:J._Michael_Bishop
|
|
gptkbp:discoveredIn
|
1982
|
|
gptkbp:encodes
|
gptkb:KRAS_protein
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000133703
3845
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:fullName
|
gptkb:Kirsten_rat_sarcoma_viral_oncogene_homolog
|
|
gptkbp:function
|
guanine nucleotide exchange factor
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasTranscriptVariant
|
2
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:6407
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
KRAS
|
|
gptkbp:involvedIn
|
apoptosis
cell differentiation
cell proliferation
cell signaling
|
|
gptkbp:length
|
189 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_12
12p12.1
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:G12V
gptkb:G13D
gptkb:Q61H
colorectal cancer
pancreatic cancer
G12D
deletion
insertion
missense
|
|
gptkbp:OMIM
|
190070
|
|
gptkbp:orthologInMouse
|
gptkb:Kras
|
|
gptkbp:pathway
|
gptkb:EGFR_signaling_pathway
gptkb:RTK-RAS_pathway
gptkb:Wnt_signaling_pathway
|
|
gptkbp:postTranslationalModification
|
farnesylation
palmitoylation
phosphorylation
|
|
gptkbp:proteinFamily
|
gptkb:Ras_family
|
|
gptkbp:regulates
|
gptkb:MAPK/ERK_pathway
gptkb:PI3K/AKT_pathway
gptkb:RalGDS_pathway
|
|
gptkbp:targetOfDrug
|
gptkb:adagrasib
gptkb:sotorasib
|
|
gptkbp:UniProtID
|
gptkb:P01116
|
|
gptkbp:bfsParent
|
gptkb:RAS
gptkb:cancer
|
|
gptkbp:bfsLayer
|
4
|