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gptkbp:instanceOf
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gptkb:protein
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gptkbp:activity
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gptkb:guanine_nucleotide_exchange_factor
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gptkbp:alsoKnownAs
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gptkb:Ras_proteins
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gptkbp:discoveredBy
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gptkb:Robert_Weinberg
gptkb:Michael_Wigler
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gptkbp:firstDescribed
|
1980s
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gptkbp:function
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signal transduction
regulation of cell differentiation
regulation of cell proliferation
regulation of cell survival
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gptkbp:hasMember
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gptkb:MRAS
gptkb:RALA
gptkb:RALB
gptkb:RAP1A
gptkb:RAP1B
gptkb:RAP2A
gptkb:RAP2B
gptkb:RAP2C
gptkb:RAPGEF1
gptkb:RAPGEF10
gptkb:RAPGEF100
gptkb:RAPGEF11
gptkb:RAPGEF12
gptkb:RAPGEF13
gptkb:RAPGEF14
gptkb:RAPGEF15
gptkb:RAPGEF16
gptkb:RAPGEF17
gptkb:RAPGEF18
gptkb:RAPGEF19
gptkb:RAPGEF2
gptkb:RAPGEF20
gptkb:RAPGEF21
gptkb:RAPGEF22
gptkb:RAPGEF23
gptkb:RAPGEF24
gptkb:RAPGEF25
gptkb:RAPGEF26
gptkb:RAPGEF27
gptkb:RAPGEF28
gptkb:RAPGEF29
gptkb:RAPGEF3
gptkb:RAPGEF30
gptkb:RAPGEF32
gptkb:RAPGEF34
gptkb:RAPGEF35
gptkb:RAPGEF36
gptkb:RAPGEF37
gptkb:RAPGEF38
gptkb:RAPGEF39
gptkb:RAPGEF4
gptkb:RAPGEF40
gptkb:RAPGEF41
gptkb:RAPGEF42
gptkb:RAPGEF43
gptkb:RAPGEF44
gptkb:RAPGEF45
gptkb:RAPGEF46
gptkb:RAPGEF47
gptkb:RAPGEF49
gptkb:RAPGEF5
gptkb:RAPGEF50
gptkb:RAPGEF52
gptkb:RAPGEF53
gptkb:RAPGEF56
gptkb:RAPGEF57
gptkb:RAPGEF58
gptkb:RAPGEF59
gptkb:RAPGEF6
gptkb:RAPGEF63
gptkb:RAPGEF64
gptkb:RAPGEF67
gptkb:RAPGEF68
gptkb:RAPGEF7
gptkb:RAPGEF70
gptkb:RAPGEF71
gptkb:RAPGEF72
gptkb:RAPGEF74
gptkb:RAPGEF75
gptkb:RAPGEF76
gptkb:RAPGEF78
gptkb:RAPGEF79
gptkb:RAPGEF8
gptkb:RAPGEF80
gptkb:RAPGEF81
gptkb:RAPGEF82
gptkb:RAPGEF83
gptkb:RAPGEF84
gptkb:RAPGEF85
gptkb:RAPGEF86
gptkb:RAPGEF87
gptkb:RAPGEF88
gptkb:RAPGEF89
gptkb:RAPGEF9
gptkb:RAPGEF90
gptkb:RAPGEF91
gptkb:RAPGEF92
gptkb:RAPGEF93
gptkb:RAPGEF94
gptkb:RAPGEF95
gptkb:RAPGEF96
gptkb:RAPGEF97
gptkb:RAPGEF98
gptkb:RAPGEF99
gptkb:RHEB
gptkb:RHEBL1
gptkb:RIT1
gptkb:RIT2
gptkb:RND1
gptkb:RND2
gptkb:RND3
gptkb:RRAS
gptkb:RRAS2
gptkb:HRAS
gptkb:KRAS
gptkb:NRAS
RAPGEF31
RAPGEF33
RAPGEF48
RAPGEF51
RAPGEF54
RAPGEF55
RAPGEF60
RAPGEF61
RAPGEF62
RAPGEF65
RAPGEF66
RAPGEF69
RAPGEF73
RAPGEF77
RERG
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gptkbp:involvedIn
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gptkb:Ral-GDS_pathway
gptkb:MAPK/ERK_pathway
gptkb:PI3K/AKT_pathway
|
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gptkbp:locatedOnChromosome
|
gptkb:chromosome_11_(HRAS)
gptkb:chromosome_12_(KRAS)
gptkb:chromosome_1_(NRAS)
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gptkbp:location
|
gptkb:cell_membrane
|
|
gptkbp:memberOf
|
gptkb:small_GTPase_superfamily
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:Cardiofaciocutaneous_syndrome
gptkb:Costello_syndrome
gptkb:Noonan_syndrome
|
|
gptkbp:postTranslationalModification
|
farnesylation
palmitoylation
prenylation
|
|
gptkbp:regulates
|
gptkb:Guanine_nucleotide_dissociation_inhibitors_(GDIs)
gptkb:Guanine_nucleotide_exchange_factors_(GEFs)
GTPase-activating proteins (GAPs)
|
|
gptkbp:structure
|
G domain
hypervariable region
|
|
gptkbp:bfsParent
|
gptkb:KRAS
gptkb:UniProt:P01112
gptkb:RAS_superfamily
|
|
gptkbp:bfsLayer
|
5
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Ras family
|