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gptkbp:instanceOf
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Cell
|
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gptkbp:affects
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gptkb:Type_1_diabetes
gptkb:Type_2_diabetes
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gptkbp:destroyedBy
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gptkb:Type_1_diabetes
|
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gptkbp:developedBy
|
Endoderm
Pancreatic progenitor cells
|
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gptkbp:dysfunctionIn
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gptkb:Type_2_diabetes
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gptkbp:firstDescribed
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gptkb:Paul_Langerhans
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gptkbp:function
|
Regulate blood glucose
Secrete insulin
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https://www.w3.org/2000/01/rdf-schema#label
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Pancreatic beta cells
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gptkbp:locatedIn
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gptkb:Islets_of_Langerhans
Pancreas
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gptkbp:marking
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gptkb:Insulin
gptkb:NKX6.1
gptkb:PDX1
MAFA
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gptkbp:modulatedBy
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gptkb:ATP
gptkb:Aging
gptkb:FOXO1
gptkb:MAPK_pathway
gptkb:Protein_kinase_B
gptkb:CREB
gptkb:Ghrelin
gptkb:Leptin
gptkb:SIRT1
gptkb:cAMP
gptkb:AMPK_pathway
gptkb:PI3K-Akt_pathway
gptkb:Protein_kinase_C
gptkb:mTOR_pathway
gptkb:Cortisol
gptkb:Wnt_signaling
gptkb:Platelet-derived_growth_factor
gptkb:Interleukin-1_beta
gptkb:cGMP
gptkb:Glucagon
gptkb:JAK-STAT_pathway
gptkb:Phospholipase_A2
gptkb:Phospholipase_C
gptkb:Phospholipase_D
gptkb:Norepinephrine
gptkb:Insulin-like_growth_factor_1
gptkb:Somatostatin
Genetic mutations
Autonomic nervous system
Hyperglycemia
G-protein coupled receptors
Hormones
Adenylate cyclase
Cytokines
Nitric oxide
Epinephrine
Acetylcholine
Notch signaling
ER stress
Reactive oxygen species
Hypoxia
Adiponectin
Calmodulin
ATP-sensitive potassium channels
Calcium signaling
Diacylglycerol
Epigenetic modifications
Fibroblast growth factor
Free fatty acids
Glucotoxicity
Growth hormone
Guanylate cyclase
Hepatocyte growth factor
Inflammatory cytokines
Inositol trisphosphate
Interferon gamma
Lipotoxicity
Oxidative stress
Paracrine signals
Potassium channels
Protein kinase A
Protein kinase G
Transforming growth factor beta
Tumor necrosis factor alpha
UCP2
Vascular endothelial growth factor
Voltage-gated calcium channels
Voltage-gated sodium channels
|
|
gptkbp:percentageOfIsletCells
|
60-80%
|
|
gptkbp:recipient
|
gptkb:Insulin_receptor
gptkb:GLP-1_receptor
gptkb:GLUT2
Sulfonylurea receptor
|
|
gptkbp:response
|
Amino acids
Fatty acids
Blood glucose
Incretins
|
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gptkbp:secretes
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gptkb:C-peptide
gptkb:Insulin
Amylin
|
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gptkbp:bfsParent
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gptkb:P21136
|
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gptkbp:bfsLayer
|
7
|