|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:activatedBy
|
gptkb:G_protein-coupled_receptors
gptkb:receptor_tyrosine_kinases
|
|
gptkbp:cofactor
|
calcium
|
|
gptkbp:discoveredBy
|
J. W. Trevan
|
|
gptkbp:EC_number
|
3.1.4.3
|
|
gptkbp:family
|
phosphodiesterase
|
|
gptkbp:firstDescribed
|
1930s
|
|
gptkbp:foundIn
|
gptkb:Bacteria
animals
plants
|
|
gptkbp:function
|
hydrolyzes phospholipids
|
|
gptkbp:gene
|
gptkb:PLCE1
gptkb:PLCG1
gptkb:PLCB1
gptkb:PLCD1
gptkb:PLCH1
gptkb:PLCH2
|
|
gptkbp:hasIsoform
|
gptkb:PLCγ
gptkb:PLCε
PLCβ
PLCδ
PLCζ
PLCη
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Phospholipase C
|
|
gptkbp:inhibitedBy
|
gptkb:U73122
edelfosine
|
|
gptkbp:locale
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:molecularWeight
|
85-150 kDa
|
|
gptkbp:product
|
gptkb:inositol_trisphosphate
diacylglycerol
|
|
gptkbp:relatedTo
|
signal transduction
second messenger system
inositol phosphate metabolism
lipid signaling
|
|
gptkbp:role
|
cell signaling
|
|
gptkbp:significance
|
gptkb:cancer
neurological disorders
bacterial toxins
|
|
gptkbp:structure
|
contains C2 domain
contains PH domain
contains X and Y domains
|
|
gptkbp:substrate
|
phosphatidylinositol 4,5-bisphosphate
|
|
gptkbp:bfsParent
|
gptkb:Phospholipase
gptkb:PLOC
|
|
gptkbp:bfsLayer
|
7
|