|
gptkbp:instanceOf
|
hormone
|
|
gptkbp:actsOn
|
hypothalamus
|
|
gptkbp:associatedWith
|
gptkb:metabolic_syndrome
obesity
leptin deficiency
|
|
gptkbp:category
|
peptide
cytokine-like hormone
|
|
gptkbp:circulatesIn
|
blood
|
|
gptkbp:deficiencyCauses
|
hyperphagia
severe obesity
|
|
gptkbp:discoveredBy
|
gptkb:Douglas_Coleman
gptkb:Jeffrey_Friedman
|
|
gptkbp:discoveredIn
|
1994
|
|
gptkbp:encodedBy
|
gptkb:LEP_gene
|
|
gptkbp:Entrez_Gene_ID
|
3952
|
|
gptkbp:firstDescribed
|
gptkb:Nature_journal
|
|
gptkbp:foundIn
|
humans
mammals
rodents
|
|
gptkbp:halfLife
|
~30 minutes
|
|
gptkbp:HGNC_ID
|
6553
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Leptin
|
|
gptkbp:influenced
|
fertility
immune function
lipid metabolism
bone formation
insulin sensitivity
thermogenesis
reproductive function
puberty onset
|
|
gptkbp:inhibitedBy
|
hunger
|
|
gptkbp:MeSH_ID
|
gptkb:D019815
|
|
gptkbp:molecularWeight
|
16 kDa
|
|
gptkbp:nameOrigin
|
from Greek 'leptos' meaning thin
|
|
gptkbp:OMIM
|
164160
|
|
gptkbp:orthologIn
|
other vertebrates
|
|
gptkbp:PDB
|
gptkb:1AX8
|
|
gptkbp:producedBy
|
adipose tissue
|
|
gptkbp:promotion
|
energy expenditure
|
|
gptkbp:PubChem_CID
|
gptkb:CHEMBL1201582
|
|
gptkbp:receptorGene
|
gptkb:LEPR
|
|
gptkbp:recipient
|
leptin receptor
|
|
gptkbp:regulates
|
appetite
energy balance
|
|
gptkbp:resistanceAssociatedWith
|
common obesity
|
|
gptkbp:structure
|
167 amino acids
|
|
gptkbp:UniProtID
|
gptkb:P41159
|
|
gptkbp:usedAs
|
therapeutic agent in rare leptin deficiency
|
|
gptkbp:bfsParent
|
gptkb:Hunger
|
|
gptkbp:bfsLayer
|
5
|