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gptkbp:instanceOf
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gptkb:enzyme
|
|
gptkbp:activatedBy
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gptkb:phosphoinositide_3-kinase_(PI3K)_pathway
gptkb:phosphatidylinositol_(3,4,5)-trisphosphate_(PIP3)
|
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gptkbp:alsoKnownAs
|
gptkb:Akt
|
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gptkbp:associatedWith
|
gptkb:cancer
gptkb:cardiovascular_disease
gptkb:diabetes
neurodegenerative disease
|
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gptkbp:discoveredBy
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gptkb:Brian_Hemmings
|
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gptkbp:discoveredIn
|
1991
|
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gptkbp:EC_number
|
2.7.11.1
|
|
gptkbp:function
|
regulation of cell proliferation
regulation of cell survival
regulation of transcription
regulation of cell growth
regulation of cell migration
regulation of glucose metabolism
serine/threonine-specific protein kinase
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Protein kinase B
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gptkbp:inhibitedBy
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gptkb:PTEN
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gptkbp:location
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gptkb:cell_membrane
gptkb:nucleus
gptkb:cytoplasm
|
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gptkbp:molecularWeight
|
~56 kDa
|
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gptkbp:phosphorylates
|
Ser473
Thr308
|
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gptkbp:proteinFamily
|
gptkb:AKT1
gptkb:AKT2
gptkb:AKT3
|
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gptkbp:regulates
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gptkb:GSK-3
gptkb:TSC2
gptkb:BAD_protein
gptkb:FOXO_transcription_factors
gptkb:MDM2
gptkb:mTOR_pathway
gptkb:eNOS
gptkb:p27Kip1
apoptosis
angiogenesis
cell cycle progression
protein synthesis
cell metabolism
glycogen synthesis
GLUT4 translocation
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gptkbp:structure
|
contains PH domain
contains kinase domain
contains regulatory domain
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gptkbp:UniProtID
|
gptkb:P31749
P31751
Q9Y243
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gptkbp:bfsParent
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gptkb:AKT
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gptkbp:bfsLayer
|
6
|