|
gptkbp:instanceOf
|
gptkb:receptor_tyrosine_kinase
gptkb:protein
|
|
gptkbp:alternativeSplicing
|
produces isoforms
|
|
gptkbp:cellularResponse
|
glucose uptake
lipid synthesis
protein synthesis
glycogen synthesis
|
|
gptkbp:discoveredBy
|
gptkb:Ora_Rosen
|
|
gptkbp:discoveredIn
|
1971
|
|
gptkbp:encodedBy
|
gptkb:INSR_gene
|
|
gptkbp:Entrez_Gene_ID
|
3643
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
gptkb:kidney
brain
liver
adipose tissue
pancreas
|
|
gptkbp:foundIn
|
gptkb:human
gptkb:mouse
right
|
|
gptkbp:function
|
mediates insulin signaling
binds insulin
|
|
gptkbp:hasBiologicalActivity
|
gptkb:receptor_tyrosine_kinase
|
|
gptkbp:hasIsoform
|
gptkb:IR-A
gptkb:IR-B
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Insulin receptor
|
|
gptkbp:interactsWith
|
gptkb:PIK3R1
gptkb:SHC1
gptkb:SOCS_proteins
gptkb:PTPN1
gptkb:GRB2
gptkb:IRS1
gptkb:IRS2
|
|
gptkbp:ligand
|
gptkb:insulin
|
|
gptkbp:location
|
gptkb:cell_membrane
|
|
gptkbp:mutationAssociatedWith
|
gptkb:Donohue_syndrome
gptkb:Rabson-Mendenhall_syndrome
gptkb:insulin_resistance_syndrome
|
|
gptkbp:OMIM
|
147670
|
|
gptkbp:pathway
|
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
|
|
gptkbp:PDB
|
gptkb:3LOH
|
|
gptkbp:phosphorylates
|
autophosphorylation
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
ubiquitination
|
|
gptkbp:relatedTo
|
gptkb:type_2_diabetes
insulin resistance
|
|
gptkbp:structure
|
heterotetramer
|
|
gptkbp:subunit
|
alpha subunit
beta subunit
|
|
gptkbp:UniProtID
|
P06213
|
|
gptkbp:bfsParent
|
gptkb:receptor_tyrosine_kinases
|
|
gptkbp:bfsLayer
|
5
|