|
gptkbp:instanceOf
|
gptkb:signaling_molecule
|
|
gptkbp:activatedBy
|
cytokines
growth factors
|
|
gptkbp:associatedWith
|
gptkb:immune_response
apoptosis
cell proliferation
hematopoiesis
|
|
gptkbp:component
|
gptkb:JAK2
gptkb:STAT1
gptkb:JAK1
gptkb:STAT2
gptkb:STAT4
gptkb:STAT5A
gptkb:STAT5B
gptkb:STAT6
gptkb:TYK2
gptkb:STAT3
gptkb:JAK3
|
|
gptkbp:discoveredBy
|
gptkb:George_Stark
gptkb:Ian_M._Kerr
gptkb:James_E._Darnell
|
|
gptkbp:dysregulationAssociatedWith
|
gptkb:cancer
gptkb:immunodeficiency
autoimmune diseases
|
|
gptkbp:foundIn
|
animals
|
|
gptkbp:function
|
transmits information from extracellular chemical signals to the cell nucleus
|
|
gptkbp:GO_term
|
gptkb:GO:0007259
|
|
gptkbp:hasWikipediaPage
|
https://en.wikipedia.org/wiki/JAK-STAT_signaling_pathway
|
|
gptkbp:inhibitedBy
|
gptkb:PIAS_proteins
gptkb:SOCS_proteins
gptkb:protein_tyrosine_phosphatases
|
|
gptkbp:involves
|
gptkb:Janus_kinases
gptkb:STAT_proteins
|
|
gptkbp:KEGGID
|
hsa04630
|
|
gptkbp:Reactome
|
R-HSA-6785807
|
|
gptkbp:regulates
|
gene expression
|
|
gptkbp:bfsParent
|
gptkb:Epidermal_Growth_Factor_Receptor_signaling_pathway
gptkb:STAT_pathway
gptkb:Signal_transduction
gptkb:IL-13
gptkb:IL-4_receptor
gptkb:IL-5_receptor
gptkb:platelet-derived_growth_factor_receptor_beta
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
JAK-STAT pathway
|