|
gptkbp:instanceOf
|
gptkb:protein
cytokine
|
|
gptkbp:alternativeName
|
gptkb:IL1B
gptkb:IL-1β
|
|
gptkbp:cleavage
|
gptkb:caspase-1
|
|
gptkbp:discoveredBy
|
Charles A. Dinarello
|
|
gptkbp:discoveredIn
|
1974
|
|
gptkbp:encodedBy
|
IL1B gene
|
|
gptkbp:Entrez_Gene_ID
|
GC01M047484
|
|
gptkbp:expressedIn
|
endothelial cells
immune cells
epithelial cells
|
|
gptkbp:family
|
Interleukin-1 family
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
mediates inflammatory response
induces fever
activates lymphocytes
stimulates production of prostaglandins
|
|
gptkbp:GO_term
|
gptkb:GO:0005125
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Interleukin-1 beta
|
|
gptkbp:inhibitedBy
|
gptkb:canakinumab
gptkb:IL-1_receptor_antagonist
gptkb:anakinra
|
|
gptkbp:involvedIn
|
sepsis
inflammatory diseases
immune response
rheumatoid arthritis
autoinflammatory syndromes
|
|
gptkbp:locatedOnChromosome
|
2q14
|
|
gptkbp:molecularWeight
|
17.5 kDa
|
|
gptkbp:OMIM
|
147720
|
|
gptkbp:pathway
|
gptkb:MAPK_signaling_pathway
gptkb:NF-kappaB_signaling_pathway
NLRP3 inflammasome pathway
|
|
gptkbp:PDB
|
2I1B
|
|
gptkbp:producedBy
|
monocytes
activated macrophages
|
|
gptkbp:promotion
|
acute phase protein synthesis
expression of adhesion molecules
production of other cytokines
|
|
gptkbp:recipient
|
IL1R1
Interleukin-1 receptor type I
|
|
gptkbp:relatedTo
|
Interleukin-1 alpha
|
|
gptkbp:structure
|
pro-protein cleaved to active form
|
|
gptkbp:target
|
gptkb:canakinumab
gptkb:anakinra
|
|
gptkbp:UniProtID
|
P01584
|
|
gptkbp:bfsParent
|
gptkb:Pancreatic_beta_cells
gptkb:P03951
gptkb:Interleukin-1
|
|
gptkbp:bfsLayer
|
8
|